Literature DB >> 27141359

Targeting abnormal ER stress responses in tumors: A new approach to cancer immunotherapy.

Juan R Cubillos-Ruiz1, Laurie H Glimcher2.   

Abstract

Cancers thrive under adverse conditions and simultaneously inhibit antitumor immunity. We recently found that endoplasmic reticulum (ER) stress responses driven by the IRE1α-XBP1 pathway not only promote cancer cell survival, but also provoke severe dendritic cell (DC) dysfunction in tumors. Targeting IRE1α-XBP1 represents a two-pronged approach to restrain malignant cells while eliciting concomitant antitumor immunity.

Entities:  

Keywords:  Cancer immunotherapy; IRE1; XBP1; dendritic cells; tumor immunology; tumor microenvironment

Year:  2015        PMID： 27141359      PMCID： PMC4839339          DOI： 10.1080/2162402X.2015.1098802

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  12 in total

Review 1.  Targeting the unfolded protein response in disease.

Authors:  Claudio Hetz; Eric Chevet; Heather P Harding
Journal:  Nat Rev Drug Discov       Date:  2013-09       Impact factor: 84.694

2.  XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.

Authors:  H Yoshida; T Matsui; A Yamamoto; T Okada; K Mori
Journal:  Cell       Date:  2001-12-28       Impact factor: 41.582

3.  Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.

Authors:  Chih-Hang Anthony Tang; Sujeewa Ranatunga; Crystina L Kriss; Christopher L Cubitt; Jianguo Tao; Javier A Pinilla-Ibarz; Juan R Del Valle; Chih-Chi Andrew Hu
Journal:  J Clin Invest       Date:  2014-05-08       Impact factor: 14.808

Review 4.  The role of X-box binding protein-1 in tumorigenicity.

Authors:  Ayesha N Shajahan; Rebecca B Riggins; Robert Clarke
Journal:  Drug News Perspect       Date:  2009-06

5.  Lipid accumulation and dendritic cell dysfunction in cancer.

Authors:  Donna L Herber; Wei Cao; Yulia Nefedova; Sergey V Novitskiy; Srinivas Nagaraj; Vladimir A Tyurin; Alex Corzo; Hyun-Il Cho; Esteban Celis; Brianna Lennox; Stella C Knight; Tapan Padhya; Thomas V McCaffrey; Judith C McCaffrey; Scott Antonia; Mayer Fishman; Robert L Ferris; Valerian E Kagan; Dmitry I Gabrilovich
Journal:  Nat Med       Date:  2010-07-11       Impact factor: 53.440

6.  Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity.

Authors:  Juan R Cubillos-Ruiz; Xavier Engle; Uciane K Scarlett; Diana Martinez; Amorette Barber; Raul Elgueta; Li Wang; Yolanda Nesbeth; Yvon Durant; Andrew T Gewirtz; Charles L Sentman; Ross Kedl; Jose R Conejo-Garcia
Journal:  J Clin Invest       Date:  2009-07-13       Impact factor: 14.808

7.  Proteasome inhibitors disrupt the unfolded protein response in myeloma cells.

Authors:  Ann-Hwee Lee; Neal N Iwakoshi; Kenneth C Anderson; Laurie H Glimcher
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-05       Impact factor: 11.205

8.  ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis.

Authors:  Juan R Cubillos-Ruiz; Pedro C Silberman; Melanie R Rutkowski; Sahil Chopra; Alfredo Perales-Puchalt; Minkyung Song; Sheng Zhang; Sarah E Bettigole; Divya Gupta; Kevin Holcomb; Lora H Ellenson; Thomas Caputo; Ann-Hwee Lee; Jose R Conejo-Garcia; Laurie H Glimcher
Journal:  Cell       Date:  2015-06-11       Impact factor: 41.582

9.  Ovarian cancer progression is controlled by phenotypic changes in dendritic cells.

Authors:  Uciane K Scarlett; Melanie R Rutkowski; Adam M Rauwerdink; Jennifer Fields; Ximena Escovar-Fadul; Jason Baird; Juan R Cubillos-Ruiz; Ana C Jacobs; Jorge L Gonzalez; John Weaver; Steven Fiering; Jose R Conejo-Garcia
Journal:  J Exp Med       Date:  2012-02-20       Impact factor: 14.307

10.  XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway.

Authors:  Dimitrios Iliopoulos; Qing Zhang; Qianzi Tang; Xi Chen; Matthew B Greenblatt; Maria Hatziapostolou; Elgene Lim; Wai Leong Tam; Min Ni; Yiwen Chen; Junhua Mai; Haifa Shen; Dorothy Z Hu; Stanley Adoro; Bella Hu; Minkyung Song; Chen Tan; Melissa D Landis; Mauro Ferrari; Sandra J Shin; Myles Brown; Jenny C Chang; X Shirley Liu; Laurie H Glimcher
Journal:  Nature       Date:  2014-03-23       Impact factor: 49.962
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  9 in total

Review 1.  Unraveling the regulatory role of endoplasmic-reticulum-associated degradation in tumor immunity.

Authors:  Xiaodan Qin; William D Denton; Leah N Huiting; Kaylee S Smith; Hui Feng
Journal:  Crit Rev Biochem Mol Biol       Date:  2020-07-07       Impact factor: 8.250

Review 2.  Endoplasmic reticulum proteostasis: a key checkpoint in cancer.

Authors:  Scott A Oakes
Journal:  Am J Physiol Cell Physiol       Date:  2016-11-16       Impact factor: 4.249

3.  Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice.

Authors:  Steven D Schutt; Yongxia Wu; Chih-Hang Anthony Tang; David Bastian; Hung Nguyen; M Hanief Sofi; MengMeng Zhang; Chen Liu; Kris Helke; Carole Wilson; Lynn M Schnapp; Juan R Del Valle; Chih-Chi Andrew Hu; Xue-Zhong Yu
Journal:  Blood Adv       Date:  2018-02-27

Review 4.  Re-Emergence of Dendritic Cell Vaccines for Cancer Treatment.

Authors:  Mansi Saxena; Nina Bhardwaj
Journal:  Trends Cancer       Date:  2018-02

5.  Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival.

Authors:  Paul C Moore; Jenny Y Qi; Maike Thamsen; Rajarshi Ghosh; Justin Peng; Micah J Gliedt; Rosa Meza-Acevedo; Rachel E Warren; Annie Hiniker; Grace E Kim; Dustin J Maly; Bradley J Backes; Feroz R Papa; Scott A Oakes
Journal:  Cancer Res       Date:  2019-10-31       Impact factor: 12.701

Review 6.  Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer.

Authors:  Juan R Cubillos-Ruiz; Eslam Mohamed; Paulo C Rodriguez
Journal:  J Immunother Cancer       Date:  2017-01-17       Impact factor: 13.751

7.  Endoplasmic reticulum stress promotes autophagy and apoptosis and reverses chemoresistance in human ovarian cancer cells.

Authors:  Jin-Long Hu; Xin-Long Hu; Ai-Ye Guo; Chao-Jie Wang; Yi-Yang Wen; Shun-Dong Cang
Journal:  Oncotarget       Date:  2017-07-25

Review 8.  Role of the early secretory pathway in SARS-CoV-2 infection.

Authors:  Daria Sicari; Aristotelis Chatziioannou; Theodoros Koutsandreas; Roberto Sitia; Eric Chevet
Journal:  J Cell Biol       Date:  2020-09-07       Impact factor: 8.077

Review 9.  The Effect of the Tumor Microenvironment and Tumor-Derived Metabolites on Dendritic Cell Function.

Authors:  Jun-Ho Lee; So-Yeon Choi; Nam-Chul Jung; Jie-Young Song; Han Geuk Seo; Hyun Soo Lee; Dae-Seog Lim
Journal:  J Cancer       Date:  2020-01-01       Impact factor: 4.207
  9 in total

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