Omar Abdel-Rahman1, Mona Fouad2. 1. Clinical Oncology Department, Faculty of medicine, Ain Shams University, Lotfy Elsayed Street, Cairo, 11331, Egypt. 2. Medical Microbiology & Immunology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Abstract
BACKGROUND: We performed a network meta-analysis of the risk of immune-related renal toxicity associated with immune checkpoint inhibitors. METHODS: Eligible studies included randomized trials of patients with immune checkpoint inhibitors; describing events of immune-related renal toxicity. RESULTS: Compared with chemotherapy control, immune checkpoint inhibitors carry a higher risk of all-grade (but not high-grade) immune-related renal toxicity. The risk with both nivolumab/ipilimumab combination was higher than the risk with either ipilimumab or nivolumab alone (odds ratio: 0.47 [95% credible interval: 0.21-0.99] and 0.11 [95% credible interval: 0.03-0.29]); for nivolumab/ipilimumab combination versus ipilimumab or nivolumab monotherapy). CONCLUSION: Our meta-analysis demonstrated that the use of immune checkpoint inhibitors is associated with an increased risk of all-grade immune-related renal toxicity compared with chemotherapy control.
BACKGROUND: We performed a network meta-analysis of the risk of immune-related renal toxicity associated with immune checkpoint inhibitors. METHODS: Eligible studies included randomized trials of patients with immune checkpoint inhibitors; describing events of immune-related renal toxicity. RESULTS: Compared with chemotherapy control, immune checkpoint inhibitors carry a higher risk of all-grade (but not high-grade) immune-related renal toxicity. The risk with both nivolumab/ipilimumab combination was higher than the risk with either ipilimumab or nivolumab alone (odds ratio: 0.47 [95% credible interval: 0.21-0.99] and 0.11 [95% credible interval: 0.03-0.29]); for nivolumab/ipilimumab combination versus ipilimumab or nivolumab monotherapy). CONCLUSION: Our meta-analysis demonstrated that the use of immune checkpoint inhibitors is associated with an increased risk of all-grade immune-related renal toxicity compared with chemotherapy control.