Literature DB >> 27139982

Polygonumnolides C1-C4; minor dianthrone glycosides from the roots of Polygonum multiflorum Thunb.

Jian-Bo Yang1,2,3, Li Li1, Zhong Dai2, Yu Wu2, Xing-Chao Geng2, Bo Li2, Shuang-Cheng Ma2,3, Ai-Guo Wang1, Ya-Lun Su1.   

Abstract

Four new dianthrone glycosides, named polygonumnolides C1-C4 (1-4), were isolated from the dried roots of Polygonum multiflorum Thunb, together with two known emodin dianthrones (5-6). Their hepatotoxicities were evaluated against L-02 cell lines. Compounds 1-4 showed weak hepatotoxicity against L-02 cell lines with IC50 values of 313.05, 205.20, 294.20, and 207.35 μM, respectively.

Entities:  

Keywords:  L-02 cell lines; Polygonum multiflorum; dianthrone glycosides; polygonumnolides C1–C4

Mesh：

Substances：

Year:  2016        PMID： 27139982     DOI： 10.1080/10286020.2016.1171758

Source DB:  PubMed          Journal:  J Asian Nat Prod Res        ISSN： 1028-6020            Impact factor:   1.569


  7 in total

1.  Hepatotoxicity of the Major Anthraquinones Derived From Polygoni Multiflori Radix Based on Bile Acid Homeostasis.

Authors:  Li Kang; Dan Li; Xin Jiang; Yao Zhang; Minhong Pan; Yixin Hu; Luqin Si; Yongjun Zhang; Jiangeng Huang
Journal:  Front Pharmacol       Date:  2022-05-18       Impact factor: 5.988

2.  Identification and characterization of the structure-activity relationships involved in UGT1A1 inhibition by anthraquinone and dianthrone constituents of Polygonum multiflorum.

Authors:  Qi Wang; Yadan Wang; Yong Li; Binyu Wen; Zhong Dai; Shuangcheng Ma; Yujie Zhang
Journal:  Sci Rep       Date:  2017-12-20       Impact factor: 4.379

Review 3.  Polygonum multiflorum-Induced Liver Injury: Clinical Characteristics, Risk Factors, Material Basis, Action Mechanism and Current Challenges.

Authors:  Yi Liu; Wenping Wang; Mingyi Sun; Baorui Ma; Linnuo Pang; Yuanyuan Du; Xiaoxv Dong; Xingbin Yin; Jian Ni
Journal:  Front Pharmacol       Date:  2019-12-13       Impact factor: 5.810

4.  A stepwise strategy integrating metabolomics and pseudotargeted spectrum-effect relationship to elucidate the potential hepatotoxic components in Polygonum multiflorum.

Authors:  Yunfei Song; Jianbo Yang; Xiaowen Hu; Huiyu Gao; Pengfei Wang; Xueting Wang; Yue Liu; Xianlong Cheng; Feng Wei; Shuangcheng Ma
Journal:  Front Pharmacol       Date:  2022-08-26       Impact factor: 5.988

5.  New phenolic constituents obtained from Polygonum multiflorum.

Authors:  Jian-Bo Yang; Hua Sun; Jie Ma; Yun-Fei Song; Yue Liu; Qi Wang; Shuang-Cheng Ma; Xian-Long Cheng; Feng Wei
Journal:  Chin Herb Med       Date:  2020-07-02

6.  UHPLC-QQQ-MS/MS assay for the quantification of dianthrones as potential toxic markers of Polygonum multiflorum Thunb: applications for the standardization of traditional Chinese medicines (TCMs) with endogenous toxicity.

Authors:  Jian-Bo Yang; Yun-Fei Song; Yue Liu; Hui-Yu Gao; Qi Wang; Ying Wang; Xian-Long Cheng; Tian-Tian Zuo; Xiao-Wen Hu; Feng Wei; Hong-Tao Jin; Shu-Ting Wang; Shuang-Cheng Ma
Journal:  Chin Med       Date:  2021-07-03       Impact factor: 5.455

Review 7.  Polygonum multiflorum Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and Hepatotoxicity.

Authors:  Yue Liu; Qi Wang; Jianbo Yang; Xiaohan Guo; Wenxi Liu; Shuangcheng Ma; Shaoping Li
Journal:  Front Pharmacol       Date:  2018-04-16       Impact factor: 5.810
  7 in total

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