Literature DB >> 2713961

Effect of cancer chemotherapy on dapsone N-acetylation in man.

P A Philip1, P G Harper, H J Rogers.   

Abstract

The effect of cancer chemotherapy on dapsone (DDS) N-acetylation was explored in 28 patients with various malignancies. There was a significant (P = 0.01) increase in plasma monoacetydapsone/dapsone (MADDS/DDS) ratios within 24 h of the start of chemotherapy (CT), indicating an acceleration of N-acetylation.

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Year:  1989        PMID： 2713961     DOI： 10.1007/BF00435844

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  7 in total

1.  Studies of the metabolism of dapsone in man and experimental animals: formation of N-hydroxy metabolites.

Authors:  Z H Israili; S A Cucinell; J Vaught; E Davis; J M Lesser; P G Dayton
Journal:  J Pharmacol Exp Ther       Date:  1973-10       Impact factor: 4.030

2.  The polymorphic acetylation of dapsone in man.

Authors:  R Gelber; J H Peters; G R Gordon; A J Glazko; L Levy
Journal:  Clin Pharmacol Ther       Date:  1971 Mar-Apr       Impact factor: 6.875

3.  Drug metabolism after repeated treatments with cytotoxic agents.

Authors:  M G Donelli; S Garattini
Journal:  Eur J Cancer       Date:  1971-08       Impact factor: 9.162

4.  Microsomal metabolism of antipyrine in rats treated with antineoplastic drugs.

Authors:  L Slørdal; T Høyem-Johansen; J Aarbakke
Journal:  Pharmacology       Date:  1983       Impact factor: 2.547

5.  A rapid method for determination of acetylation phenotype using dapsone.

Authors:  P A Philip; M S Roberts; H J Rogers
Journal:  Br J Clin Pharmacol       Date:  1984-04       Impact factor: 4.335

Review 6.  Genetically determined variability in acetylation and oxidation. Therapeutic implications.

Authors:  D W Clark
Journal:  Drugs       Date:  1985-04       Impact factor: 9.546

7.  Antipyrine metabolism in patients with disseminated testicular cancer and the influence of cytostatic treatment.

Authors:  M W Teunissen; P H Willemse; D T Sleijfer; W J Sluiter; D D Breimer
Journal:  Cancer Chemother Pharmacol       Date:  1984       Impact factor: 3.333
  7 in total
  1 in total

1.  The kinetics of the auto-induction of ifosfamide metabolism during continuous infusion.

Authors:  A V Boddy; M Cole; A D Pearson; J R Idle
Journal:  Cancer Chemother Pharmacol       Date:  1995       Impact factor: 3.333
  1 in total

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