Literature DB >> 2713960

Pharmacokinetics of prednisolone in children with acute lymphoblastic leukaemia.

I Choonara1, J Wheeldon, P Rayner, M Blackburn, I Lewis.   

Abstract

The pharmacokinetics of soluble oral prednisolone were studied during induction therapy in six children with acute lymphoblastic leukaemia. There was a three- to four-fold variation in the pharmacokinetics of total and free prednisolone. For total prednisolone, the mean elimination half-life was relatively short (1.37 h) and the total clearance, relatively high (15.1 ml min-1 kg-1). The mean free fraction was high (0.37).

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Year:  1989        PMID： 2713960     DOI： 10.1007/BF00435843

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  18 in total

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Authors:  M G Donelli; G Franchi; R Rosso
Journal:  Eur J Cancer       Date:  1970-04       Impact factor: 9.162

2.  Glucocorticoid receptors in childhood acute lymphocytic leukemia.

Authors:  M E Costlow; C H Pui; G V Dahl
Journal:  Cancer Res       Date:  1982-11       Impact factor: 12.701

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Authors:  E S Vesell; G T Passananti; F E Greene
Journal:  N Engl J Med       Date:  1970-12-31       Impact factor: 91.245

4.  Studies of the effects of cyclophosphamide, vincristine, and prednisone on some hepatic oxidations and conjugations.

Authors:  H L Gurtoo; T Gessner; P Culliton
Journal:  Cancer Treat Rep       Date:  1976-09

5.  The effect of age, gender, and sexual maturation on the caffeine breath test.

Authors:  G H Lambert; D A Schoeller; A N Kotake; C Flores; D Hay
Journal:  Dev Pharmacol Ther       Date:  1986

6.  Hepatic drug clearance in children with leukemia: changes in clearance of model substrates during remission-induction therapy.

Authors:  M V Relling; W R Crom; J A Pieper; G C Cupit; G K Rivera; W E Evans
Journal:  Clin Pharmacol Ther       Date:  1987-06       Impact factor: 6.875

7.  Methotrexate systemic clearance influences probability of relapse in children with standard-risk acute lymphocytic leukaemia.

Authors:  W E Evans; W R Crom; C F Stewart; W P Bowman; C H Chen; M Abromowitch; J V Simone
Journal:  Lancet       Date:  1984-02-18       Impact factor: 79.321

8.  Pharmacokinetics of prednisone and its metabolite prednisolone in children with nephrotic syndrome during the active phase and in remission.

Authors:  G Gatti; E Perucca; G M Frigo; L D Notarangelo; L Barberis; A Martini
Journal:  Br J Clin Pharmacol       Date:  1984-04       Impact factor: 4.335

9.  Variation in 17 oxogenic steroid excretion following oral prednisolone in children with lymphoblastic leukaemia.

Authors:  J S Lilleyman; A J French; I P Young
Journal:  Oncology       Date:  1981       Impact factor: 2.935

10.  Prednisolone and methylprednisolone kinetics in children receiving anticonvulsant therapy.

Authors:  M Bartoszek; A M Brenner; S J Szefler
Journal:  Clin Pharmacol Ther       Date:  1987-10       Impact factor: 6.875
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  1 in total

1.  Evaluation of the pharmacokinetics of prednisolone in paediatric patients with acute lymphoblastic leukaemia treated according to Dutch Childhood Oncology Group protocols and its relation to treatment response.

Authors:  Sebastiaan D T Sassen; Ron A A Mathôt; Rob Pieters; Valérie de Haas; Gertjan J L Kaspers; Cor van den Bos; Wim J E Tissing; D Maroeska W W Te Loo; Marc B Bierings; Inge M van der Sluis; C Michel Zwaan
Journal:  Br J Haematol       Date:  2021-06-01       Impact factor: 6.998
  1 in total

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