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Literature DB >> 27139465

Stability of Novel Siderophore Cephalosporin S-649266 against Clinically Relevant Carbapenemases.

Tsukasa Ito-Horiyama¹, Yoshikazu Ishii², Akinobu Ito¹, Takafumi Sato³, Rio Nakamura¹, Norio Fukuhara⁴, Masakatsu Tsuji¹, Yoshinori Yamano¹, Keizo Yamaguchi², Kazuhiro Tateda².

Abstract

To better understand the antibacterial activity of S-649266 against carbapenemase producers, its stability against clinically relevant carbapenemases was investigated. The catalytic efficiencies (kcat/Km) of IMP-1, VIM-2, and L1 for S-649266 were 0.0048, 0.0050, and 0.024 μM(-1) s(-1), respectively, which were more than 260-fold lower than that for meropenem. Only slight hydrolysis of S-649266 against KPC-3 was observed. NDM-1 hydrolyzed meropenem 3-fold faster than S-649266 at 200 μM.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2016 PMID： 27139465 PMCID： PMC4914688 DOI： 10.1128/AAC.03098-15

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

12 in total

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