Mikiko Harada1, Atsushi Izawa2, Hiroya Hidaka3, Keisuke Nakanishi4, Fumiko Terasawa3, Hirohiko Motoki1, Yoshikazu Yazaki5, Uichi Ikeda1, Minoru Hongo3. 1. Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan. 2. Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan; School of Health Sciences, Shinshu University School of Medicine, Matsumoto, Nagano, Japan. Electronic address: izawa611@shinshu-u.ac.jp. 3. School of Health Sciences, Shinshu University School of Medicine, Matsumoto, Nagano, Japan. 4. School of Health Sciences, Shinshu University School of Medicine, Matsumoto, Nagano, Japan; Department of Nursing, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan. 5. Saku Central Hospital, Saku, Nagano, Japan.
Abstract
BACKGROUND: Serum cystatin C (CysC), a novel marker of renal function, is associated with the components of metabolic syndrome in adults. Little is known about the utility of CysC and its association with cardiometabolic risks in young subjects. METHODS AND RESULTS: In a cohort of 454 Japanese junior high school students, the distribution of serum CysC levels and associated variables were analyzed. CysC levels were significantly higher in boys than in girls (0.92±0.10mg/L vs. 0.77±0.08mg/L, p<0.001). CysC was significantly correlated with serum creatinine (r=0.473, p<0.001), and serum uric acid (SUA) (r=0.546, p<0.001). Multivariable regression analysis revealed significant associations between CysC and SUA in all subjects (β=0.241, p<0.001), and in boys and girls separately (β=0.264 and 0.240, respectively, both p<0.001). Importantly, subjects with elevation of both serum CysC and SUA levels had the highest ratio of triglyceride to high-density lipoprotein cholesterol. CONCLUSIONS: CysC had significant associations with both creatinine and SUA in Japanese junior high school students. The concomitant elevation of serum CysC and SUA levels was associated with subclinical lipid metabolism dysregulation, and suggested the presence of cardiometabolic risk accumulation.
BACKGROUND: Serum cystatin C (CysC), a novel marker of renal function, is associated with the components of metabolic syndrome in adults. Little is known about the utility of CysC and its association with cardiometabolic risks in young subjects. METHODS AND RESULTS: In a cohort of 454 Japanese junior high school students, the distribution of serum CysC levels and associated variables were analyzed. CysC levels were significantly higher in boys than in girls (0.92±0.10mg/L vs. 0.77±0.08mg/L, p<0.001). CysC was significantly correlated with serum creatinine (r=0.473, p<0.001), and serum uric acid (SUA) (r=0.546, p<0.001). Multivariable regression analysis revealed significant associations between CysC and SUA in all subjects (β=0.241, p<0.001), and in boys and girls separately (β=0.264 and 0.240, respectively, both p<0.001). Importantly, subjects with elevation of both serum CysC and SUA levels had the highest ratio of triglyceride to high-density lipoprotein cholesterol. CONCLUSIONS:CysC had significant associations with both creatinine and SUA in Japanese junior high school students. The concomitant elevation of serum CysC and SUA levels was associated with subclinical lipidmetabolism dysregulation, and suggested the presence of cardiometabolic risk accumulation.
Authors: Cristiane Fernanda da Silva; Miria Suzana Burgos; Priscila Tatiana da Silva; Leandro Tibiriçá Burgos; Letícia Welser; Ana Paula Sehn; Jorge André Horta; Elza Daniel de Mello; Cézane Priscila Reuter Journal: Arq Bras Cardiol Date: 2017-07-20 Impact factor: 2.000
Authors: Maria Pallayova; Marek Brenisin; Alina Putrya; Martin Vrsko; Sylvia Drazilova; Martin Janicko; Maria Marekova; Daniel Pella; Andrea Madarasova Geckova; Peter Urdzik; Peter Jarcuska; HepaMeta Team Journal: Int J Environ Res Public Health Date: 2020-10-21 Impact factor: 3.390