Literature DB >> 27138179

Fusogen-assisted rapid reconstitution of anatomophysiologic continuity of the transected spinal cord.

Yijie Ye1, C-Yoon Kim2, Qing Miao1, Xiaoping Ren3.   

Abstract

The GEMINI spinal cord fusion protocol exploits the ability of so-called fusogens, such as polyethylene glycol (PEG), to achieve rapid neural restoration of electrical continuity across the ends of a transected spinal cord. Experimental evidence suggests that motor recovery can occur after complete transection of the cervical and dorsal spinal cord in mice and rats following application of PEG. This allows for the possibility of spinal cord "reconstruction" in humans and even the possibility of head transplantation in the future.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID: 27138179     DOI: 10.1016/j.surg.2016.03.023

Source DB:  PubMed          Journal:  Surgery        ISSN: 0039-6060            Impact factor:   3.982


  13 in total

1.  Polyethylene glycol-induced motor recovery after total spinal transection in rats.

Authors:  Shuai Ren; Ze-Han Liu; Qiong Wu; Kuang Fu; Jun Wu; Li-Ting Hou; Ming Li; Xin Zhao; Qing Miao; Yun-Long Zhao; Sheng-Yu Wang; Yan Xue; Zhen Xue; Ya-Shan Guo; Sergio Canavero; Xiao-Ping Ren
Journal:  CNS Neurosci Ther       Date:  2017-06-14       Impact factor: 5.243

2.  Partial restoration of spinal cord neural continuity via vascular pedicle hemisected spinal cord transplantation using spinal cord fusion technique.

Authors:  Xiaoping Ren; Weihua Zhang; Jie Qin; Jian Mo; Yi Chen; Jie Han; Xinjian Feng; Sitan Feng; Haibo Liang; Liangjue Cen; Xiaofei Wu; Linxuan Han; Rongyu Lan; Haixuan Deng; Huihui Yao; Zhongquan Qi; Hongjun Gao; Lishan Wei; Shuai Ren
Journal:  CNS Neurosci Ther       Date:  2022-05-12       Impact factor: 7.035

3.  Immunohistochemical evidence of axonal regrowth across polyethylene glycol-fused cervical cords in mice.

Authors:  C-Yoon Kim; Hanseul Oh; Xiaoping Ren; Sergio Canavero
Journal:  Neural Regen Res       Date:  2017-01       Impact factor: 5.135

4.  Biocompatibility of reduced graphene oxide nanoscaffolds following acute spinal cord injury in rats.

Authors:  Ali H Palejwala; Jared S Fridley; Javier A Mata; Errol L G Samuel; Thomas G Luerssen; Laszlo Perlaky; Thomas A Kent; James M Tour; Andrew Jea
Journal:  Surg Neurol Int       Date:  2016-08-23

5.  Houston, GEMINI has landed: Spinal cord fusion achieved.

Authors:  Sergio Canavero; Xiaoping Ren
Journal:  Surg Neurol Int       Date:  2016-09-13

6.  GEMINI: Initial behavioral results after full severance of the cervical spinal cord in mice.

Authors:  C-Yoon Kim; Hanseul Oh; In-Kyu Hwang; Ki-Sung Hong
Journal:  Surg Neurol Int       Date:  2016-09-13

7.  Accelerated recovery of sensorimotor function in a dog submitted to quasi-total transection of the cervical spinal cord and treated with PEG.

Authors:  C-Yoon Kim; In-Kyu Hwang; Hana Kim; Se-Woong Jang; Hong Seog Kim; Won-Young Lee
Journal:  Surg Neurol Int       Date:  2016-09-13

8.  HEAVEN: The Frankenstein effect.

Authors:  Sergio Canavero; XiaoPing Ren; C Yoon Kim
Journal:  Surg Neurol Int       Date:  2016-09-13

9.  First cephalosomatic anastomosis in a human model.

Authors:  Xiaoping Ren; Ming Li; Xin Zhao; Zehan Liu; Shuai Ren; Yafang Zhang; Shide Zhang; Sergio Canavero
Journal:  Surg Neurol Int       Date:  2017-11-17

10.  Spinal cord fusion with PEG-GNRs (TexasPEG): Neurophysiological recovery in 24 hours in rats.

Authors:  C-Yoon Kim; William K A Sikkema; In-Kyu Hwang; Hanseul Oh; Un Jeng Kim; Bae Hwan Lee; James M Tour
Journal:  Surg Neurol Int       Date:  2016-09-13
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