Yoshisato Tanimoto1, Hirotaka Tashiro2, Yoshihiro Mikuriya1, Shintaro Kuroda1, Masakazu Hashimoto1, Tsuyoshi Kobayashi1, Tokunori Taniura3, Hideki Ohdan1. 1. Department of Gastroenterological and Transplant Surgery, University of Hiroshima, 1-2-3, Kasumi, Hiroshima, 734-8551, Japan. 2. Department of Surgery, Kure medical Center, National Hospital Organization, 3-1, Aoyama, Kure City, Hiroshima, 737-0023, Japan. htashiro@hiroshima-u.ac.jp. 3. Taniura Animal Hospital, 1-3-30, Kairoen, Saiki-Ku, Hiroshima, 731-5135, Japan.
Abstract
BACKGROUND: Biliary stricture is a common cause of morbidity after liver transplantation. We previously developed a duct-to-duct biliary anastomosis technique using a biodegradable stent tube and confirmed the feasibility and safety of biliary stent use. However, the duration and mechanism of biliary stent absorption in the common bile duct remain unclear. MATERIALS AND METHODS: Radiopaque biodegradable biliary stents were created using a copolymer of L-lactide and ε-caprolactone (70: 30) and coated with barium sulfate. Stents were surgically implanted in the common bile duct of 11 pigs. Liver function tests and computed tomography (CT) scans were performed postoperatively, and autopsies were conducted 6 months after biliary stent implantation. RESULTS: After the surgery, all 11 pigs had normal liver function and survived without any significant complications such as biliary leakage. A CT scan at 2 months post-procedure showed that the biliary stents were located in the hilum of the liver. The stents were not visible by CT scan at the 6-month follow-up examination. CONCLUSIONS: The surgical implantation of radiopaque biodegradable biliary stents in biliary surgery represents a new option for duct-to-duct biliary reconstruction. This technique appears to be feasible and safe and is not associated with any significant biliary complications. The advantage of coated biliary stent use is that it may be visualized using abdominal radiography such as CT.
BACKGROUND: Biliary stricture is a common cause of morbidity after liver transplantation. We previously developed a duct-to-duct biliary anastomosis technique using a biodegradable stent tube and confirmed the feasibility and safety of biliary stent use. However, the duration and mechanism of biliary stent absorption in the common bile duct remain unclear. MATERIALS AND METHODS: Radiopaque biodegradable biliary stents were created using a copolymer of L-lactide and ε-caprolactone (70: 30) and coated with barium sulfate. Stents were surgically implanted in the common bile duct of 11 pigs. Liver function tests and computed tomography (CT) scans were performed postoperatively, and autopsies were conducted 6 months after biliary stent implantation. RESULTS: After the surgery, all 11 pigs had normal liver function and survived without any significant complications such as biliary leakage. A CT scan at 2 months post-procedure showed that the biliary stents were located in the hilum of the liver. The stents were not visible by CT scan at the 6-month follow-up examination. CONCLUSIONS: The surgical implantation of radiopaque biodegradable biliary stents in biliary surgery represents a new option for duct-to-duct biliary reconstruction. This technique appears to be feasible and safe and is not associated with any significant biliary complications. The advantage of coated biliary stent use is that it may be visualized using abdominal radiography such as CT.
Authors: Gabriel E Gondolesi; Giovanni Varotti; Sander S Florman; Luis Muñoz; Thomas M Fishbein; Sukru H Emre; Myron E Schwartz; Charles Miller Journal: Transplantation Date: 2004-06-27 Impact factor: 4.939
Authors: Chang-Il Kwon; Sung Hoon Choi; Kyu Seok Kim; Jong Pil Moon; Sehwan Park; Jinkyung Jeon; Gwangil Kim; Jae Young Jang; Min Je Sung; Kwang Hyun Ko; Jun Sik Son Journal: Ann Surg Treat Res Date: 2022-02-04 Impact factor: 1.859