Literature DB >> 2713657

Translocation of zinc may contribute to seizure-induced death of neurons.

C J Frederickson1, M D Hernandez, J F McGinty.   

Abstract

Rats were subjected to seizures induced by kainic acid, and the resulting changes in CNS zinc staining were studied with the toluene sulfonamide quinoline fluorescence method. Seizures caused a loss of zinc staining from presynaptic boutons in many limbic and cerebrocortical regions. Simultaneously, the postsynaptic neurons that were degenerating (acidophilic) in those regions as a result of the seizure developed intense fluorescence for zinc. A possible role for zinc in the death of the postsynaptic neurons is suggested.

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Year:  1989        PMID： 2713657     DOI： 10.1016/0006-8993(89)90199-6

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  53 in total

1.  Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity.

Authors:  P Manzerra; M M Behrens; L M Canzoniero; X Q Wang; V Heidinger; T Ichinose; S P Yu; D W Choi
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-25       Impact factor: 11.205

2.  Fluorophilia: fluorophore-containing compounds adhere non-specifically to injured neurons.

Authors:  Bridget E Hawkins; Christopher J Frederickson; Douglas S Dewitt; Donald S Prough
Journal:  Brain Res       Date:  2011-11-11       Impact factor: 3.252

3.  Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic beta-cell function.

Authors:  Malek El Muayed; Liana K Billings; Meera R Raja; Xiaomin Zhang; Paul J Park; Marsha V Newman; Dixon B Kaufman; Thomas V O'Halloran; William L Lowe
Journal:  J Endocrinol       Date:  2010-05-27       Impact factor: 4.286

4.  Expression of zinc transporter gene, ZnT-1, is induced after transient forebrain ischemia in the gerbil.

Authors:  M Tsuda; K Imaizumi; T Katayama; K Kitagawa; A Wanaka; M Tohyama; T Takagi
Journal:  J Neurosci       Date:  1997-09-01       Impact factor: 6.167

5.  Measurement of intracellular free zinc in living cortical neurons: routes of entry.

Authors:  S L Sensi; L M Canzoniero; S P Yu; H S Ying; J Y Koh; G A Kerchner; D W Choi
Journal:  J Neurosci       Date:  1997-12-15       Impact factor: 6.167

6.  Nitric oxide decreases the sensitivity of pulmonary endothelial cells to LPS-induced apoptosis in a zinc-dependent fashion.

Authors:  Zi-Lue Tang; Karla J Wasserloos; Xianghong Liu; Molly S Stitt; Ian J Reynolds; Bruce R Pitt; Claudette M St Croix
Journal:  Mol Cell Biochem       Date:  2002 May-Jun       Impact factor: 3.396

7.  Serum zinc in the progression of Alzheimer's disease.

Authors:  Jiang Dong; J David Robertson; William R Markesbery; Mark A Lovell
Journal:  J Alzheimers Dis       Date:  2008-11       Impact factor: 4.472

8.  Endogenous zinc mediates apoptotic programmed cell death in the developing brain.

Authors:  Eunsil Cho; Jung-Jin Hwang; Seung-Hee Han; Sun Ju Chung; Jae-Young Koh; Joo-Yong Lee
Journal:  Neurotox Res       Date:  2009-07-17       Impact factor: 3.911

9.  Zn2+-dependent Activation of the Trk Signaling Pathway Induces Phosphorylation of the Brain-enriched Tyrosine Phosphatase STEP: MOLECULAR BASIS FOR ZN2+-INDUCED ERK MAPK ACTIVATION.

Authors:  Ranjana Poddar; Sathyanarayanan Rajagopal; C William Shuttleworth; Surojit Paul
Journal:  J Biol Chem       Date:  2015-11-16       Impact factor: 5.157

10.  Endogenous zinc in neurological diseases.

Authors:  Jae-Yong Koh
Journal:  J Clin Neurol       Date:  2005-10-20       Impact factor: 3.077
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