Julia Souza-Queiroz1, Jennifer Boisgontier2, Bruno Etain3, Cyril Poupon4, Delphine Duclap4, Marc-Antoine d'Albis2, Claire Daban3, Nora Hamdani3, Philippe Le Corvoisier5, Marine Delavest6, Frank Bellivier6, Pamela Guevara7, Marion Leboyer3, Chantal Henry8, Josselin Houenou9. 1. CAPES Foundation, Ministry of Education of Brazil, Brasília/DF 70040-020, Brazil; Fondation FondaMental, Créteil, France; INSERM, U955, équipe 15 "Psychiatrie Translationnelle", IMRB, Créteil, France. 2. AP-HP, Hôpitaux H. Mondor, DHU PePsy, Pôle de Psychiatrie, Créteil, France; Faculté de Médecine, Université Paris Est, Créteil, France; Fondation FondaMental, Créteil, France; INSERM, U955, équipe 15 "Psychiatrie Translationnelle", IMRB, Créteil, France; Neurospin, UNIACT Lab, Psychiatry Team, CEA Saclay, Gif sur Yvette, France. 3. AP-HP, Hôpitaux H. Mondor, DHU PePsy, Pôle de Psychiatrie, Créteil, France; Faculté de Médecine, Université Paris Est, Créteil, France; Fondation FondaMental, Créteil, France; INSERM, U955, équipe 15 "Psychiatrie Translationnelle", IMRB, Créteil, France. 4. Neurospin, UNIRS Lab, CEA Saclay, Gif Sur Yvette, France. 5. AP-HP, Centre d'Investigation Clinique, Hôpitaux Henri Mondor, Créteil, France. 6. Fondation FondaMental, Créteil, France; Inserm, Université Paris Diderot, UMR-S 1144, Paris, France; AP-HP, GH Saint-Louis - Lariboisière - Fernand Widal, Pôle Neurosciences, Paris, France. 7. Faculty of Engineering, University of Concepción, Concepción, Chile. 8. AP-HP, Hôpitaux H. Mondor, DHU PePsy, Pôle de Psychiatrie, Créteil, France; Faculté de Médecine, Université Paris Est, Créteil, France; Fondation FondaMental, Créteil, France; INSERM, U955, équipe 15 "Psychiatrie Translationnelle", IMRB, Créteil, France; Institut Pasteur, Unité Perception et Mémoire, F-75015 Paris, France. 9. AP-HP, Hôpitaux H. Mondor, DHU PePsy, Pôle de Psychiatrie, Créteil, France; Faculté de Médecine, Université Paris Est, Créteil, France; Fondation FondaMental, Créteil, France; INSERM, U955, équipe 15 "Psychiatrie Translationnelle", IMRB, Créteil, France; Neurospin, UNIACT Lab, Psychiatry Team, CEA Saclay, Gif sur Yvette, France. Electronic address: josselin.houenou@inserm.fr.
Abstract
BACKGROUND: Childhood trauma (CT) is a major risk factor for psychiatric conditions. It is hypothesized that CT effects are mediated by the limbic system. Few multimodal neuroimaging studies allow an integrated perspective of this impact. Our goal was thus to study the effects of CT on the limbic network. METHODS: We acquired multimodal MRI (T1, diffusion weighted, and resting state fMRI) data from 79 subjects (47 healthy controls and 32 patients with bipolar disorder, BD). We performed correlational analyses between Childhood Trauma Questionnaire (sub)scores (physical and emotional abuse/neglect and sexual abuse) and anatomo-functional measurements of the limbic network (hippocampal and amygdala volumes, prefronto-limbic functional connectivity, uncinate fractional anisotropy). RESULTS: We found CTQ total scores to be negatively correlated with amygdala volume, prefronto-limbic functional connectivity (FC) and uncinate fractional anisotropy in our sample. Considering subscores, neglects (physical and emotional) were the only to affect neural parameters. The patients with BD drove most of the results. LIMITATIONS: Small sample size and low level of trauma in controls. CONCLUSIONS: Our multimodal approach enabled an integrated view of the long-term effects of CT on the limbic system.
BACKGROUND: Childhood trauma (CT) is a major risk factor for psychiatric conditions. It is hypothesized that CT effects are mediated by the limbic system. Few multimodal neuroimaging studies allow an integrated perspective of this impact. Our goal was thus to study the effects of CT on the limbic network. METHODS: We acquired multimodal MRI (T1, diffusion weighted, and resting state fMRI) data from 79 subjects (47 healthy controls and 32 patients with bipolar disorder, BD). We performed correlational analyses between Childhood Trauma Questionnaire (sub)scores (physical and emotional abuse/neglect and sexual abuse) and anatomo-functional measurements of the limbic network (hippocampal and amygdala volumes, prefronto-limbic functional connectivity, uncinate fractional anisotropy). RESULTS: We found CTQ total scores to be negatively correlated with amygdala volume, prefronto-limbic functional connectivity (FC) and uncinate fractional anisotropy in our sample. Considering subscores, neglects (physical and emotional) were the only to affect neural parameters. The patients with BD drove most of the results. LIMITATIONS: Small sample size and low level of trauma in controls. CONCLUSIONS: Our multimodal approach enabled an integrated view of the long-term effects of CT on the limbic system.
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