Dilnasheen Meerza1, Sarah Iqbal1, Sufian Zaheer2, Imrana Naseem3. 1. Department of Biochemistry, Aligarh Muslim University, Aligarh, India. 2. Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India. 3. Department of Biochemistry, Aligarh Muslim University, Aligarh, India. Electronic address: Imrananaseem2009@gmail.com.
Abstract
OBJECTIVE: Uncontrolled diabetes is associated with a compromised antioxidant state of the body. Consequentially, the reactive oxygen species generated lead to oxidative insult and associated complications. Based on this paradigm, exogenous antioxidant supplementation is thought to exert a therapeutic role in type 2 diabetes (T2-D) biology. METHODS: In the present study, the effect of vitamin A supplementation was assessed on disease progression in T2-D BALB/c mice. Animals were divided into three groups. With the exception of control, the mice in remaining groups were induced with experimental T2-D. After a 15-day treatment protocol, the mice were sacrificed and various parameters were analyzed. RESULTS: The treated group evidenced a considerable improvement in total antioxidant potential and glycemic control. A therapeutic effect on beta cell degeneration as compared to the diabetic group was also found. CONCLUSIONS: The study illustrates the antihyperglycemic and antioxidant potential of vitamin A in vivo, which has potential to serve as a dietary intervention in T2-D.
OBJECTIVE: Uncontrolled diabetes is associated with a compromised antioxidant state of the body. Consequentially, the reactive oxygen species generated lead to oxidative insult and associated complications. Based on this paradigm, exogenous antioxidant supplementation is thought to exert a therapeutic role in type 2 diabetes (T2-D) biology. METHODS: In the present study, the effect of vitamin A supplementation was assessed on disease progression in T2-D BALB/c mice. Animals were divided into three groups. With the exception of control, the mice in remaining groups were induced with experimental T2-D. After a 15-day treatment protocol, the mice were sacrificed and various parameters were analyzed. RESULTS: The treated group evidenced a considerable improvement in total antioxidant potential and glycemic control. A therapeutic effect on beta cell degeneration as compared to the diabetic group was also found. CONCLUSIONS: The study illustrates the antihyperglycemic and antioxidant potential of vitamin A in vivo, which has potential to serve as a dietary intervention in T2-D.
Authors: Tara Ahanian; Philip Curman; Ivone U S Leong; Kerstin Brismar; Etty Bachar-Wikstrom; Martin Cederlöf; Jakob D Wikstrom Journal: Diabetol Metab Syndr Date: 2020-02-05 Impact factor: 3.320