Megan G Berger1, Kaustav Majumder2, James S Hodges3, Melena D Bellin4, Sarah Jane Schwarzenberg5, Sameer Gupta5, Ty B Dunn2, Gregory J Beilman2, Timothy L Pruett2, Martin L Freeman6, Joshua J Wilhelm7, David E R Sutherland8, Srinath Chinnakotla9. 1. Department of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA. Electronic address: roone083@umn.edu. 2. Department of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA. 3. Department of Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN, USA. 4. Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA; Schulze Diabetes Institute, University of Minnesota Medical School, Minneapolis, MN, USA. 5. Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA. 6. Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA. 7. Schulze Diabetes Institute, University of Minnesota Medical School, Minneapolis, MN, USA. 8. Department of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA; Schulze Diabetes Institute, University of Minnesota Medical School, Minneapolis, MN, USA. 9. Department of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA; Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
Abstract
BACKGROUND/ OBJECTIVES: Total pancreatectomy and islet autotransplant (TP-IAT) is a potential treatment for children with severe refractory chronic pancreatitis. Cultures from the resected pancreas and final islet preparation are frequently positive for microbes. It is unknown whether positive cultures are associated with adverse outcomes in pediatric patients. METHODS: We reviewed the medical records of children (n = 86) who underwent TP-IAT from May 2006-March 2015 with emphasis on demographics, previous pancreatic interventions, culture results, islet yield, hospital days, posttransplant islet function, and posttransplant infections. We compared outcomes in patients with positive (n = 57) and negative (n = 29) cultures. RESULTS: Patients with positive cultures had higher rates of previous pancreas surgery (P = 0.007) and endoscopic retrograde cholangiopancreatography (P < 0.0001). Positive cultures were not associated with posttransplant infections (P = 1.00) or prolonged hospital length of stay (P = 0.29). Patients with positive final islet preparation culture showed increased rates of graft failure at 2 years posttransplant (P = 0.041), but not when adjusted for islet mass transplanted (P = 0.39). CONCLUSIONS: Positive cultures during pediatric TP-IATs do not increase the risk of posttransplant infections or prolong hospital length of stay. Endocrine function depends on islet mass transplanted.
BACKGROUND/ OBJECTIVES: Total pancreatectomy and islet autotransplant (TP-IAT) is a potential treatment for children with severe refractory chronic pancreatitis. Cultures from the resected pancreas and final islet preparation are frequently positive for microbes. It is unknown whether positive cultures are associated with adverse outcomes in pediatric patients. METHODS: We reviewed the medical records of children (n = 86) who underwent TP-IAT from May 2006-March 2015 with emphasis on demographics, previous pancreatic interventions, culture results, islet yield, hospital days, posttransplant islet function, and posttransplant infections. We compared outcomes in patients with positive (n = 57) and negative (n = 29) cultures. RESULTS:Patients with positive cultures had higher rates of previous pancreas surgery (P = 0.007) and endoscopic retrograde cholangiopancreatography (P < 0.0001). Positive cultures were not associated with posttransplant infections (P = 1.00) or prolonged hospital length of stay (P = 0.29). Patients with positive final islet preparation culture showed increased rates of graft failure at 2 years posttransplant (P = 0.041), but not when adjusted for islet mass transplanted (P = 0.39). CONCLUSIONS: Positive cultures during pediatric TP-IATs do not increase the risk of posttransplant infections or prolong hospital length of stay. Endocrine function depends on islet mass transplanted.
Authors: Joshua S Jolissaint; Linda W Langman; Claire L DeBolt; Jacob A Tatum; Allison N Martin; Andrew Y Wang; Daniel S Strand; Victor M Zaydfudim; Reid B Adams; Kenneth L Brayman Journal: Clin Transplant Date: 2016-10-17 Impact factor: 2.863
Authors: Varvara A Kirchner; Ty B Dunn; Gregory J Beilman; Srinath Chinnakotla; Timothy L Pruett; Joshua J Wilhelm; Sarah J Schwarzenberg; Martin L Freeman; Melena D Bellin Journal: Curr Treat Options Gastroenterol Date: 2017-12
Authors: Guru Trikudanathan; B Joseph Elmunzer; Yi Yang; Maisam Abu-El-Haija; David Adams; Syed Ahmad; Appakalai N Balamurugan; Gregory J Beilman; Srinath Chinnakotla; Darwin L Conwell; Martin L Freeman; Timothy B Gardner; Betul Hatipoglu; James S Hodges; Varvara Kirchner; Luis F Lara; Leslie Long-Simpson; Rebecca Mitchell; Katherine Morgan; Jaimie D Nathan; Bashoo Naziruddin; Andrew Posselt; Timothy L Pruett; Sarah J Schwarzenberg; Vikesh K Singh; Kerrington Smith; Martin Wijkstrom; Piotr Witkowski; Melena D Bellin Journal: Pancreatology Date: 2020-11-24 Impact factor: 3.996