S Haufe1, H Witt2, S Engeli1, J Kaminski3, W Utz4, J C Fuhrmann2, D Rein2, J Schulz-Menger4, F C Luft3, M Boschmann3, J Jordan5. 1. Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany. 2. Metanomics Health GmbH, Berlin, Germany. 3. Franz Volhard Clinical Research Center at the Experimental and Clinical Research Center, Charité University Medical School and Max Delbrück Center for Molecular Medicine, Berlin, Germany. 4. Working Group Cardiac MRI, Clinic for Cardiology and Nephrology, HELIOS Klinikum Berlin-Buch, Germany; University Medicine Berlin, Charité Campus Buch, and Experimental and Clinical Research Centre Berlin, Germany. 5. Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany. Electronic address: jordan.jens@mh-hannover.de.
Abstract
BACKGROUND & AIMS:Amino acids may interfere with insulin action, particularly in obese individuals. We hypothesized that increased circulating branched-chain and aromatic amino acids herald insulin resistance and ectopic fat storage, particularly hepatic fat accumulation. METHODS AND RESULTS: We measured fasting branched-chain and aromatic amino acids (tryptophan, tyrosine, and phenylalanine) by mass spectrometry in 111 overweight to obese subjects. We applied abdominal magnetic resonance imaging and spectroscopy to assess adipose tissue distribution and ectopic fat storage, respectively. Plasma branched-chain amino acids concentrations were related to insulin sensitivity and intrahepatic fat independent from adiposity, age and gender, but not to abdominal adipose tissue or intramyocellular fat. CONCLUSIONS: In weight stable overweight and obese individuals, branched-chain amino acid concentrations are specifically associated with hepatic fat storage and insulin resistance.
RCT Entities:
BACKGROUND & AIMS: Amino acids may interfere with insulin action, particularly in obese individuals. We hypothesized that increased circulating branched-chain and aromatic amino acids herald insulin resistance and ectopic fat storage, particularly hepatic fat accumulation. METHODS AND RESULTS: We measured fasting branched-chain and aromatic amino acids (tryptophan, tyrosine, and phenylalanine) by mass spectrometry in 111 overweight to obese subjects. We applied abdominal magnetic resonance imaging and spectroscopy to assess adipose tissue distribution and ectopic fat storage, respectively. Plasma branched-chain amino acids concentrations were related to insulin sensitivity and intrahepatic fat independent from adiposity, age and gender, but not to abdominal adipose tissue or intramyocellular fat. CONCLUSIONS: In weight stable overweight and obese individuals, branched-chain amino acid concentrations are specifically associated with hepatic fat storage and insulin resistance.
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