Jianlin Xu1, Bo Jin1, Tianqing Chu1, Xue Dong1, Haitang Yang2, Yanwei Zhang1, Dan Wu3, Yuqing Lou1, Xueyan Zhang1, Huiming Wang1, Baohui Han4. 1. Department of Pulmonary, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China. 2. Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China. 3. Central laboratory, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China. 4. Department of Pulmonary, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China. Electronic address: xkyyhan@gmail.com.
Abstract
INTRODUCTION: There are a number of uncommon EGFR mutations whose associations with TKIs are not well clarified. Here, we summarize the clinical data of patients with multiple uncommon EGFR mutations and their sensitivity to EGFR TKIs. METHODS: Between January 2009 and September 2014, we retrospectively examined stage IIIB/IV NSCLC patients harboring uncommon mutations in EGFR at the Shanghai Chest Hospital. RESULTS: A total of 123 NSCLC patients harboring uncommon EGFR mutations with treatment and survival details were included in this analysis. 95 Patients who received therapy that consisted of EGFR TKIs experienced a significantly improved overall survival (OS) compared with those who did not receive EGFR TKIs (18.96 months, 95% CI, 16.65-21.26 vs 12.22, 95% CI, 9.17-15.27, p=0.017). The median progression-free survival (PFS) for patients who harbored the L861Q, G719X, 20ins, Del-19+L858R, Del-19 or L858R+T790M, and the Del-19 or L858R+other mutations were 8.90 months (95% CI, 4.47-13.34), 5.98 months (95% CI, 1.53-10.42), 2.00 months (95% CI, 0.00-5.41), 9.53 months (95% CI, 0.00-19.41), 1.94 months (95% CI, 0.00-4.43), and 9.79 months (95% CI, 0.73-18.85), respectively. The best objective response rates (ORRs) for patients who harbored L861Q, G719X, 20ins, Del-19+L858R, Del-19 or L858R+T790M, Del-19 or L858R+others were 46.7%, 42.9%, 8.3%, 71.4%, 22.2%, and 55.6%, respectively. CONCLUSIONS: These results suggest that EGFR TKI therapy is effective in patients with L861Q/G719X/Del-19+L858R/Del-19 or L858R+other mutations; less effective in patients with 20ins/Del-19 or L858R+T790M.
INTRODUCTION: There are a number of uncommon EGFR mutations whose associations with TKIs are not well clarified. Here, we summarize the clinical data of patients with multiple uncommon EGFR mutations and their sensitivity to EGFR TKIs. METHODS: Between January 2009 and September 2014, we retrospectively examined stage IIIB/IV NSCLCpatients harboring uncommon mutations in EGFR at the Shanghai Chest Hospital. RESULTS: A total of 123 NSCLCpatients harboring uncommon EGFR mutations with treatment and survival details were included in this analysis. 95 Patients who received therapy that consisted of EGFR TKIs experienced a significantly improved overall survival (OS) compared with those who did not receive EGFR TKIs (18.96 months, 95% CI, 16.65-21.26 vs 12.22, 95% CI, 9.17-15.27, p=0.017). The median progression-free survival (PFS) for patients who harbored the L861Q, G719X, 20ins, Del-19+L858R, Del-19 or L858R+T790M, and the Del-19 or L858R+other mutations were 8.90 months (95% CI, 4.47-13.34), 5.98 months (95% CI, 1.53-10.42), 2.00 months (95% CI, 0.00-5.41), 9.53 months (95% CI, 0.00-19.41), 1.94 months (95% CI, 0.00-4.43), and 9.79 months (95% CI, 0.73-18.85), respectively. The best objective response rates (ORRs) for patients who harbored L861Q, G719X, 20ins, Del-19+L858R, Del-19 or L858R+T790M, Del-19 or L858R+others were 46.7%, 42.9%, 8.3%, 71.4%, 22.2%, and 55.6%, respectively. CONCLUSIONS: These results suggest that EGFR TKI therapy is effective in patients with L861Q/G719X/Del-19+L858R/Del-19 or L858R+other mutations; less effective in patients with 20ins/Del-19 or L858R+T790M.
Authors: Tuo Zhang; Beibei Sun; Chenxi Zhong; Ke Xu; Zhexin Wang; Paul Hofman; Tatsuya Nagano; Antoine Legras; Daniel Breadner; Biagio Ricciuti; Duilio Divisi; Ralph A Schmid; Ren-Wang Peng; Haitang Yang; Feng Yao Journal: Transl Lung Cancer Res Date: 2021-04
Authors: Ruxu You; Jinyu Liu; David Bin-Chia Wu; XinYu Qian; Boxiang Lyu; Yu Zhang; Nan Luo Journal: Cancer Manag Res Date: 2019-12-05 Impact factor: 3.989