Diane Dunst1, Justin M Ream2, Victoria Khalef3, Cristina H Hajdu4, Andrew B Rosenkrantz5. 1. Department of Radiology, NYU School of Medicine, NYU Langone Medical Center, 550 First Avenue, New York, NY, 10016. Electronic address: diane.belvin@gmail.com. 2. Department of Radiology, NYU School of Medicine, NYU Langone Medical Center, 550 First Avenue, New York, NY, 10016. Electronic address: Justin.ream@nyumc.org. 3. Department of Radiology, NYU School of Medicine, NYU Langone Medical Center, 550 First Avenue, New York, NY, 10016. Electronic address: victoria.khalef@gmail.com. 4. Department of Pathology, NYU School of Medicine, NYU Langone Medical Center, 550 First Avenue, New York, NY, 10016. Electronic address: Cristina.hajdu@nyumc.org. 5. Department of Radiology, NYU School of Medicine, NYU Langone Medical Center, 550 First Avenue, New York, NY, 10016. Electronic address: Andrew.rosenkrantz@nyumc.org.
Abstract
PURPOSE: To compare MRI features of pathologically-proven hepatocellular carcinoma (HCC) between patients with hepatitis B (HBV) and hepatitis C (HCV) infection. METHODS: Two radiologists assessed 51 confirmed HCCs on MRI in HBV (n=18) or HCV (n=33) patients; a third, more experienced, radiologist resolved discrepancies. RESULTS: Arterial hyperenhancement occurred more frequently in HCV (90.9% vs. 66.7%; P=.032), DWI/T2WI hyperintensity more frequently in HBV [(DWI: 78.6% vs. 45.8%, T2WI: 77.8% vs. 48.5%; P=.073-0.088)]. Tumors were larger in HBV (P≤.016). Washout, pseudocapsule, homogeneity, circumscribed margins, lipid, iron, and visually low ADC were not different. CONCLUSION: Larger studies are required to confirm these preliminary findings.
PURPOSE: To compare MRI features of pathologically-proven hepatocellular carcinoma (HCC) between patients with hepatitis B (HBV) and hepatitis C (HCV) infection. METHODS: Two radiologists assessed 51 confirmed HCCs on MRI in HBV (n=18) or HCV (n=33) patients; a third, more experienced, radiologist resolved discrepancies. RESULTS: Arterial hyperenhancement occurred more frequently in HCV (90.9% vs. 66.7%; P=.032), DWI/T2WI hyperintensity more frequently in HBV [(DWI: 78.6% vs. 45.8%, T2WI: 77.8% vs. 48.5%; P=.073-0.088)]. Tumors were larger in HBV (P≤.016). Washout, pseudocapsule, homogeneity, circumscribed margins, lipid, iron, and visually low ADC were not different. CONCLUSION: Larger studies are required to confirm these preliminary findings.
Authors: Roman Kloeckner; Daniel Pinto Dos Santos; Karl-Friedrich Kreitner; Anne Leicher-Düber; Arndt Weinmann; Jens Mittler; Christoph Düber Journal: BMC Cancer Date: 2016-09-29 Impact factor: 4.430