Literature DB >> 2713220

Adenosine-induced respiratory and heart rate changes in young and elderly adults.

A H Watt1, A Bayer, P A Routledge, C G Swift.   

Abstract

The effects of intravenous boluses of adenosine on respiration and heart rate were compared in young and elderly individuals. Respiratory stimulation and biphasic changes in heart rate were confirmed. The dose-response relationship for the effects of adenosine on respiration and heart-rate did not differ significantly between 10 young (mean age 25.2 +/- 4.9 years) and 10 elderly (mean age 66 +/- 3.1 years) drug-free individuals, indicating that age is unlikely to be a major determinant of adenosine responsiveness.

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Year:  1989        PMID： 2713220      PMCID： PMC1379789          DOI： 10.1111/j.1365-2125.1989.tb05360.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  13 in total

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2.  Reduced beta-adrenoceptor sensitivity in the elderly.

Authors:  R E Vestal; A J Wood; D G Shand
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4.  Alterations in leukocyte beta-receptor affinity with aging. A potential explanation for altered beta-adrenergic sensitivity in the elderly.

Authors:  R D Feldman; L E Limbird; J Nadeau; D Robertson; A J Wood
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5.  Inhibition of lipolysis by adenosine is potentiated with age.

Authors:  B B Hoffman; H Chang; Z Farahbakhsh; G Reaven
Journal:  J Clin Invest       Date:  1984-11       Impact factor: 14.808

6.  Mechanism of adenosine inhibition of catecholamine-induced responses in heart.

Authors:  J G Dobson
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7.  Effect of age on the responsiveness of vascular alpha-adrenoceptors in man.

Authors:  H L Elliott; D J Sumner; K McLean; J L Reid
Journal:  J Cardiovasc Pharmacol       Date:  1982 May-Jun       Impact factor: 3.105

8.  Isoproterenol responsiveness and myocardial beta-adrenergic receptors in young and old rats.

Authors:  I B Abrass; J L Davis; P J Scarpace
Journal:  J Gerontol       Date:  1982-03

9.  Decreased response with age of the cardiac catecholamine sensitive adenylate cyclase system.

Authors:  J W Kusiak; J Pitha
Journal:  Life Sci       Date:  1983-10-24       Impact factor: 5.037

10.  Transient bradycardia and subsequent sinus tachycardia produced by intravenous adenosine in healthy adult subjects.

Authors:  A H Watt; P A Routledge
Journal:  Br J Clin Pharmacol       Date:  1986-05       Impact factor: 4.335
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  5 in total

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2.  Dipyridamole myocardial SPECT with low heart rate response indicates cardiac autonomic dysfunction in patients with diabetes.

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Review 3.  Adenosine. An evaluation of its use in cardiac diagnostic procedures, and in the treatment of paroxysmal supraventricular tachycardia.

Authors:  D Faulds; P Chrisp; M M Buckley
Journal:  Drugs       Date:  1991-04       Impact factor: 9.546

4.  Age-related changes in adenosine and beta-adrenoceptor responsiveness of vascular smooth muscle in man.

Authors:  G A Ford; B B Hoffman; R E Vestal; T F Blaschke
Journal:  Br J Clin Pharmacol       Date:  1992-01       Impact factor: 4.335

Review 5.  Caffeine and the elderly.

Authors:  L K Massey
Journal:  Drugs Aging       Date:  1998-07       Impact factor: 3.923
  5 in total

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