Vinod Chainani1, Sameer Shaharyar1, Kairavee Dave1, Vivek Choksi1, Sharmila Ravindranathan2, Ram Hanno2, Omar Jamal1, Abir Abdo3, Nidal Abi Rafeh4. 1. Aventura Hospital and Medical Center, United States. 2. Tulane University School of Medicine, Heart and Vascular Institute, United States. 3. Louisiana State University School of Medicine, Internal Medicine Department, Section of Geriatrics, United States. 4. Tulane University School of Medicine, Heart and Vascular Institute, United States. Electronic address: nidal.abirafeh@gmail.com.
Abstract
BACKGROUND: Handgrip strength (HGS) and gait speed (GS) are objective components of the frailty syndrome in the elderly, and are associated with increased all-cause mortality. However, their association with cardiovascular (CVD) mortality is less lucid. The present systematic review aims to summarize the available literature assessing HGS, GS and their association with CVD Mortality. METHODS: Medline and Embase databases were searched systematically using controlled vocabulary and free text terms. A total of 344 results were obtained and scanned for inclusion. Articles were included if they presented results of original research and provided information on HGS or GS and CVD mortality. RESULTS: A total of 19 studies (N=63,396) were included for review. Twelve studies examined hand grip strength with CVD mortality and 7 studies assessed gait speed. Almost all included studies demonstrated an association of HGS/GS with CVD mortality on univariate analyses. Decreased HGS or GS were associated with increased mortality in most studies (8/12 for HGS and 6/7 for GS). In most positive studies, the association of HGS/GS was usually found to be independent of traditional CVD risk factors. CONCLUSION: The present review demonstrates that decreased HGS and GS are associated with CVD mortality, with the association found to be more consistent for GS as compared to HGS. Both of these measures provide valuable prognostic information above and beyond traditional scoring methods and should be considered for implementation in clinical practice. Published by Elsevier Ireland Ltd.
BACKGROUND: Handgrip strength (HGS) and gait speed (GS) are objective components of the frailty syndrome in the elderly, and are associated with increased all-cause mortality. However, their association with cardiovascular (CVD) mortality is less lucid. The present systematic review aims to summarize the available literature assessing HGS, GS and their association with CVD Mortality. METHODS: Medline and Embase databases were searched systematically using controlled vocabulary and free text terms. A total of 344 results were obtained and scanned for inclusion. Articles were included if they presented results of original research and provided information on HGS or GS and CVD mortality. RESULTS: A total of 19 studies (N=63,396) were included for review. Twelve studies examined hand grip strength with CVD mortality and 7 studies assessed gait speed. Almost all included studies demonstrated an association of HGS/GS with CVD mortality on univariate analyses. Decreased HGS or GS were associated with increased mortality in most studies (8/12 for HGS and 6/7 for GS). In most positive studies, the association of HGS/GS was usually found to be independent of traditional CVD risk factors. CONCLUSION: The present review demonstrates that decreased HGS and GS are associated with CVD mortality, with the association found to be more consistent for GS as compared to HGS. Both of these measures provide valuable prognostic information above and beyond traditional scoring methods and should be considered for implementation in clinical practice. Published by Elsevier Ireland Ltd.
Authors: Naila Ijaz; Brian Buta; Qian-Li Xue; Denise T Mohess; Archana Bushan; Henry Tran; Wayne Batchelor; Christopher R deFilippi; Jeremy D Walston; Karen Bandeen-Roche; Daniel E Forman; Jon R Resar; Christopher M O'Connor; Gary Gerstenblith; Abdulla A Damluji Journal: J Am Coll Cardiol Date: 2022-02-08 Impact factor: 24.094
Authors: Preethi Srikanthan; Tamara B Horwich; Marcella Calfon Press; Jeff Gornbein; Karol E Watson Journal: J Am Heart Assoc Date: 2021-02-23 Impact factor: 5.501