| Literature DB >> 2713164 |
T Okamoto1, T Matsuyama, S Mori, Y Hamamoto, N Kobayashi, N Yamamoto, S F Josephs, F Wong-Staal, K Shimotohno.
Abstract
It is now well established that cytokines are involved in the regulation of gene expression from HIV-1 LTR. The present study provides evidence that TNF-alpha stimulates HIV-1 gene expression and that the enhancer sequence within the HIV-1 LTR is involved in the stimulation. These results support the idea that immunologic stimulation and infection may trigger the development of clinical AIDS in individuals latently infected with HIV-1.Entities:
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Year: 1989 PMID： 2713164 DOI： 10.1089/aid.1989.5.131
Source DB: PubMed Journal: AIDS Res Hum Retroviruses ISSN： 0889-2229 Impact factor: 2.205