| Literature DB >> 27130819 |
Rami Al-Haddad1, Nabil Karnib1, Rawad Abi Assaad1, Yara Bilen1, Nancy Emmanuel1, Anthony Ghanem1, Joe Younes1, Victor Zibara1, Joseph S Stephan2, Sama F Sleiman3.
Abstract
The incidence of diabetes is increasing worldwide. Diabetes is quickly becoming one of the leading causes of death. Diabetes is a genetic disease; however, the environment plays critical roles in its development and progression. Epigenetic changes often translate environmental stimuli to changes in gene expression. Changes in epigenetic marks and differential regulation of epigenetic modulators have been observed in different models of diabetes and its associated complications. In this minireview, we will focus DNA methylation, Histone acetylation and methylation and their roles in the pathogenesis of diabetes.Entities:
Keywords: DNA methylation; Diabetes; Epigenetics; HDACs
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Year: 2016 PMID： 27130819 DOI： 10.1016/j.neulet.2016.04.046
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046