Literature DB >> 27130578

Misclassification of Antiretroviral Treatment Failure Using WHO 2006 and 2010/2013 Immunologic Criteria in HIV-Infected Children and Adolescents in Western Kenya.

Elizabeth M Dufort1,2, Allison K DeLong3, Marita Mann4, Winstone M Nyandiko5, Samuel O Ayaya5, Joseph W Hogan3,6, Rami Kantor7.   

Abstract

We evaluated treatment failure misclassification in human immunodeficiency virus-infected Kenyan children whose targeted viral loads were determined after suspected immunologic/clinical failure according to 2006 and 2010/2013 World Health Organization guidelines. The misclassification rate was 21% for the 2006 guidelines and 46% for the 2010/2013 guidelines, which supports current recommendations for routine viral load monitoring but not necessarily the proposed CD4 thresholds.
© The Author 2016. Published by Oxford University Press on behalf of the Pediatric Infectious Diseases Society. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  failure; pediatric HIV; treatment

Mesh：

Substances：

Year:  2017        PMID： 27130578      PMCID： PMC5907858          DOI： 10.1093/jpids/piw018

Source DB:  PubMed          Journal:  J Pediatric Infect Dis Soc        ISSN： 2048-7193            Impact factor:   3.164


  8 in total

1.  Accuracy of immunological criteria for identifying virological failure in children on antiretroviral therapy - the IeDEA Southern Africa Collaboration.

Authors:  Mary-Ann Davies; Andrew Boulle; Brian Eley; Harry Moultrie; Karl Technau; Helena Rabie; Gilles van Cutsem; Janet Giddy; Robin Wood; Matthias Egger; Olivia Keiser
Journal:  Trop Med Int Health       Date:  2011-08-11       Impact factor: 2.622

2.  Viability and effectiveness of large-scale HIV treatment initiatives in sub-Saharan Africa: experience from western Kenya.

Authors:  Kara Wools-Kaloustian; Silvester Kimaiyo; Lameck Diero; Abraham Siika; John Sidle; Constantin T Yiannoutsos; Beverly Musick; Robert Einterz; Kenneth H Fife; William M Tierney
Journal:  AIDS       Date:  2006-01-02       Impact factor: 4.177

3.  Outcomes of HIV-infected orphaned and non-orphaned children on antiretroviral therapy in western Kenya.

Authors:  Winstone M Nyandiko; Samuel Ayaya; Esther Nabakwe; Constance Tenge; John E Sidle; Constantin T Yiannoutsos; Beverly Musick; Kara Wools-Kaloustian; William M Tierney
Journal:  J Acquir Immune Defic Syndr       Date:  2006-12-01       Impact factor: 3.731

4.  Prediction of treatment failure using 2010 World Health Organization Guidelines is associated with high misclassification rates and drug resistance among HIV-infected Cambodian children.

Authors:  Benjamin P Westley; Allison K DeLong; Chhraing S Tray; Dim Sophearin; Elizabeth M Dufort; Eric Nerrienet; Leeann Schreier; Joseph I Harwell; Rami Kantor
Journal:  Clin Infect Dis       Date:  2012-04-26       Impact factor: 9.079

5.  Misclassification of first-line antiretroviral treatment failure based on immunological monitoring of HIV infection in resource-limited settings.

Authors:  Rami Kantor; Lameck Diero; Allison Delong; Lydia Kamle; Sarah Muyonga; Fidelis Mambo; Eunice Walumbe; Wilfred Emonyi; Philip Chan; E Jane Carter; Joseph Hogan; Nathan Buziba
Journal:  Clin Infect Dis       Date:  2009-08-01       Impact factor: 9.079

6.  An electronic medical record system for ambulatory care of HIV-infected patients in Kenya.

Authors:  Abraham M Siika; Joseph K Rotich; Chrispinus J Simiyu; Erica M Kigotho; Faye E Smith; John E Sidle; Kara Wools-Kaloustian; Sylvester N Kimaiyo; Winston M Nyandiko; Terry J Hannan; William M Tierney
Journal:  Int J Med Inform       Date:  2005-06       Impact factor: 4.046

7.  Predictors of long-term viral failure among ugandan children and adults treated with antiretroviral therapy.

Authors:  Moses R Kamya; Harriet Mayanja-Kizza; Andrew Kambugu; Sabrina Bakeera-Kitaka; Fred Semitala; Patricia Mwebaze-Songa; Barbara Castelnuovo; Petra Schaefer; Lisa A Spacek; Anne F Gasasira; Elly Katabira; Robert Colebunders; Thomas C Quinn; Allan Ronald; David L Thomas; Adeodata Kekitiinwa
Journal:  J Acquir Immune Defic Syndr       Date:  2007-10-01       Impact factor: 3.731

Review 8.  Predicting treatment failure in adults and children on antiretroviral therapy: a systematic review of the performance characteristics of the 2010 WHO immunologic and clinical criteria for virologic failure.

Authors:  George W Rutherford; Andrew Anglemyer; Philippa J Easterbrook; Tara Horvath; Marco Vitoria; Martina Penazzato; Meg C Doherty
Journal:  AIDS       Date:  2014-03       Impact factor: 4.177
  8 in total

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