| Literature DB >> 27130416 |
Abstract
Brain vasculature acts in synergism with neurons to maintain brain function. This neurovascular coupling, or trophic coupling between cerebral endothelium and neuron, is now well accepted as a marker for mapping brain activity. Neurovascular coupling is most active in the perivascular region, in which there are ample opportunities for cell-cell interactions within the neurovascular unit. This trophic coupling between cells maintains neurovascular function and cellular plasticity. Recent studies have revealed that even adult brains contain multiple stem cells of various lineages, which may provide cellular plasticity through the process of differentiation among these stem cell populations. In this chapter, we provide an overview of the process by which neurovascular components contribute to cellular plasticity in the cerebral perivascular regions, focusing on mechanisms of cell-cell interaction in adult brain.Entities:
Keywords: Neurogenesis; Neurovascular coupling; Neurovascular niche; Neurovascular unit; Oligodendrogenesis; Oligovascular niche; Perivascular region
Mesh：
Year: 2016 PMID： 27130416 PMCID： PMC5332144 DOI： 10.1016/bs.pbr.2016.03.005
Source DB: PubMed Journal: Prog Brain Res ISSN： 0079-6123 Impact factor: 2.453