H Niu1, I Álvarez-Álvarez2, F Guillén-Grima3, I Aguinaga-Ontoso2. 1. Departamento de Ciencias de la Salud, Universidad Pública de Navarra, Pamplona, Navarra, España. Electronic address: niu.74609@e.unavarra.es. 2. Departamento de Ciencias de la Salud, Universidad Pública de Navarra, Pamplona, Navarra, España. 3. Departamento de Ciencias de la Salud, Universidad Pública de Navarra, Pamplona, Navarra, España; Instituto de Investigación Sanitaria de Navarra (IDISNA), Pamplona, Navarra, España; Medicina Preventiva, Clínica Universidad de Navarra, Pamplona, Navarra, España.
Abstract
BACKGROUND: A disease of unknown aetiology, Alzheimer's disease (AD) is the most common type of dementia. As the elderly population grows worldwide, the number of patients with AD also increases rapidly. The aim of this meta-analysis is to evaluate the prevalence and incidence of AD in Europe. METHODOLOGY: We conducted a literature search on Medline, Scopus, and CINAHL Complete using the keywords «Alzheimer», «Alzheimer's disease», and «AD» combined with «prevalence», «incidence», and «epidemiology». A Bayesian random effects model with 95% credible intervals was used. The I2 statistic was applied to assess heterogeneity. RESULTS: The prevalence of Alzheimer's disease in Europe was estimated at 5.05% (95% CI, 4.73-5.39). The prevalence in men was 3.31% (95% CI, 2.85-3.80) and in women, 7.13% (95% CI, 6.56-7.72), and increased with age. The incidence of Alzheimer's disease in Europe was 11.08 per 1000 person-years (95% CI, 10.30-11.89). Broken down by sex, it was 7.02 per 1000 person-years (95% CI, 6.06-8.05) in men and 13.25 per 1000 person-years (95% CI, 12.05-14.51) in women; again these rates increased with age. CONCLUSIONS: The results of our meta-analysis allow a better grasp of the impact of this disease in Europe.
BACKGROUND: A disease of unknown aetiology, Alzheimer's disease (AD) is the most common type of dementia. As the elderly population grows worldwide, the number of patients with AD also increases rapidly. The aim of this meta-analysis is to evaluate the prevalence and incidence of AD in Europe. METHODOLOGY: We conducted a literature search on Medline, Scopus, and CINAHL Complete using the keywords «Alzheimer», «Alzheimer's disease», and «AD» combined with «prevalence», «incidence», and «epidemiology». A Bayesian random effects model with 95% credible intervals was used. The I2 statistic was applied to assess heterogeneity. RESULTS: The prevalence of Alzheimer's disease in Europe was estimated at 5.05% (95% CI, 4.73-5.39). The prevalence in men was 3.31% (95% CI, 2.85-3.80) and in women, 7.13% (95% CI, 6.56-7.72), and increased with age. The incidence of Alzheimer's disease in Europe was 11.08 per 1000 person-years (95% CI, 10.30-11.89). Broken down by sex, it was 7.02 per 1000 person-years (95% CI, 6.06-8.05) in men and 13.25 per 1000 person-years (95% CI, 12.05-14.51) in women; again these rates increased with age. CONCLUSIONS: The results of our meta-analysis allow a better grasp of the impact of this disease in Europe.
Authors: Danielle Klinger; Brian L Hill; Noam Barda; Eran Halperin; Ofer N Gofrit; Charles L Greenblatt; Nadav Rappoport; Michal Linial; Hervé Bercovier Journal: Vaccines (Basel) Date: 2021-05-11
Authors: Jairo E Martinez; Enmanuelle Pardilla-Delgado; Edmarie Guzmán-Vélez; Clara Vila-Castelar; Rebecca Amariglio; Jennifer Gatchel; Daniel C Aguirre-Acevedo; Yamile Bocanegra; Ana Baena; Eliana Henao; Victoria Tirado; Claudia Muñoz; Margarita Giraldo-Chica; Francisco Lopera; Yakeel T Quiroz Journal: J Int Neuropsychol Soc Date: 2021-06-30 Impact factor: 3.114
Authors: Lauren Edwards; Renaud La Joie; Leonardo Iaccarino; Amelia Strom; Suzanne L Baker; Kaitlin B Casaletto; Yann Cobigo; Harli Grant; Minseon Kim; Joel H Kramer; Taylor J Mellinger; Julie Pham; Katherine L Possin; Howard J Rosen; David N Soleimani-Meigooni; Amy Wolf; Bruce L Miller; Gil D Rabinovici Journal: Neurobiol Aging Date: 2021-04-22 Impact factor: 5.133