PURPOSE: The goal of this study was to examine the symptom burden (SB) and quality of life (QOL) in patients with metastatic breast cancer. METHODS: Breast cancer patients with metastases were asked to complete the Edmonton Symptom Assessment System (ESAS) and FACT-B questionnaires. Statistical analysis was performed to identify (1) any differences in SB and QOL between patients with bone metastases only and patients with visceral +/- bone metastases and (2) any associations between SB and/or QOL and various clinical factors, including treatment with bisphosphonates, participation in a clinical trial and presence of brain metastases. RESULTS: A total of 174 patients were enrolled. Treatment with bisphosphonates was significantly associated with lower ESAS well-being scores (less symptoms) in patients with bone metastases only. In this same group, receiving treatment prior to diagnosis of metastases was significantly associated with increased fatigue, anxiety and dyspnoea. The presence of brain metastases was associated with higher physical well-being scores (increased QOL). Participation in clinical trials was associated with better QOL. CONCLUSION: Breast cancer patients with metastases have different SB and QOL in relation to the type of the metastases, treatment interventions and participation in clinical trials.
PURPOSE: The goal of this study was to examine the symptom burden (SB) and quality of life (QOL) in patients with metastatic breast cancer. METHODS:Breast cancerpatients with metastases were asked to complete the Edmonton Symptom Assessment System (ESAS) and FACT-B questionnaires. Statistical analysis was performed to identify (1) any differences in SB and QOL between patients with bone metastases only and patients with visceral +/- bone metastases and (2) any associations between SB and/or QOL and various clinical factors, including treatment with bisphosphonates, participation in a clinical trial and presence of brain metastases. RESULTS: A total of 174 patients were enrolled. Treatment with bisphosphonates was significantly associated with lower ESAS well-being scores (less symptoms) in patients with bone metastases only. In this same group, receiving treatment prior to diagnosis of metastases was significantly associated with increased fatigue, anxiety and dyspnoea. The presence of brain metastases was associated with higher physical well-being scores (increased QOL). Participation in clinical trials was associated with better QOL. CONCLUSION:Breast cancerpatients with metastases have different SB and QOL in relation to the type of the metastases, treatment interventions and participation in clinical trials.
Entities:
Keywords:
Metastatic breast cancer; Quality of life; Symptom burden
Authors: M J Brady; D F Cella; F Mo; A E Bonomi; D S Tulsky; S R Lloyd; S Deasy; M Cobleigh; G Shiomoto Journal: J Clin Oncol Date: 1997-03 Impact factor: 44.544
Authors: I J Diel; J-J Body; M R Lichinitser; E D Kreuser; W Dornoff; V A Gorbunova; M Budde; B Bergström Journal: Eur J Cancer Date: 2004-07 Impact factor: 9.162
Authors: Kevin P Weinfurt; Liana D Castel; Yun Li; Justin W Timbie; G Alastair Glendenning; Kevin A Schulman Journal: Med Care Date: 2004-02 Impact factor: 2.983
Authors: Annette Ø Jensen; Jacob B Jacobsen; Mette Nørgaard; Mellissa Yong; Jon P Fryzek; Henrik T Sørensen Journal: BMC Cancer Date: 2011-01-24 Impact factor: 4.430
Authors: Su Jin Lee; Silvia Park; Hee Kyung Ahn; Jun Ho Yi; Eun Yoon Cho; Jong Mu Sun; Jeong Eon Lee; Seok Jin Nam; Jung-Hyun Yang; Yeon Hee Park; Jin Seok Ahn; Young-Hyuck Im Journal: Cancer Res Treat Date: 2011-06-30 Impact factor: 4.679
Authors: Araba A Adjei; Camden L Lopez; Daniel J Schaid; Jeff A Sloan; Jennifer G Le-Rademacher; Charles L Loprinzi; Aaron D Norman; Janet E Olson; Fergus J Couch; Andreas S Beutler; Celine M Vachon; Kathryn J Ruddy Journal: Cancers (Basel) Date: 2021-02-10 Impact factor: 6.639
Authors: Marloes E Clarijs; Jacob Thurell; Friedrich Kühn; Carin A Uyl-de Groot; Elham Hedayati; Maria M Karsten; Agnes Jager; Linetta B Koppert Journal: Cancers (Basel) Date: 2021-05-12 Impact factor: 6.639