| Literature DB >> 27129429 |
Yo-El S Ju1, Mary Beth Finn1,2,3, Courtney L Sutphen1,2,3, Elizabeth M Herries4, Gina M Jerome1,2,3, Jack H Ladenson4, Daniel L Crimmins4, Anne M Fagan1,2,3, David M Holtzman1,2,3.
Abstract
We hypothesized that one mechanism underlying the association between obstructive sleep apnea (OSA) and Alzheimer's disease is OSA leading to decreased slow wave activity (SWA), increased synaptic activity, decreased glymphatic clearance, and increased amyloid-β. Polysomnography and lumbar puncture were performed in OSA and control groups. SWA negatively correlated with cerebrospinal fluid (CSF) amyloid-β-40 among controls and was decreased in the OSA group. Unexpectedly, amyloid-β-40 was decreased in the OSA group. Other neuronally derived proteins, but not total protein, were also decreased in the OSA group, suggesting that OSA may affect the interaction between interstitial and cerebrospinal fluid. Ann Neurol 2016;80:154-159.Entities:
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Year: 2016 PMID： 27129429 PMCID： PMC5120585 DOI： 10.1002/ana.24672
Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422