Sylvia Lehmann1, Steffen Leonhardt2, Chuong Ngo2, Lukas Bergmann2, Ines Ayed2, Simone Schrading3, Klaus Tenbrock4. 1. Division of Pediatric Pulmonology, Department of Pediatrics, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany. slehmann@ukaachen.de. 2. Philips Chair for Medical Information Technology, RWTH Aachen, Aachen, Germany. 3. Department of Radiology, University Hospital RWTH Aachen, Aachen, Germany. 4. Division of Pediatric Pulmonology, Department of Pediatrics, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
Abstract
BACKGROUND: Electrical impedance tomography (EIT) delivers information about global and regional ventilation. Linearity of EIT during tidal breathing is known. We investigated the feasibility of EIT during lung function tests in pediatric patients with cystic fibrosis (CF) and healthy controls. METHODS: Eleven CF patients and 11 age-matched controls underwent spirometry and simultaneous EIT. Global EIT results were scaled to spirometric forced vital capacity (FVC). Subsequently, global and regional "EIT-spirometry" was calculated and correlated with clinical findings, radiology, and lung function results before and after bronchospasmolysis (BSL). RESULTS: Spirometry and global EIT results correlated essentially (r2 = 0.71-1.0, P < 0.001). While lung function results were comparable for both groups, EIT demonstrated inhomogeneous ventilation and individual changes after BSL. CONCLUSIONS: EIT changes during forced expiration correlate with lung function parameters, clinical findings, and radiology. Regional analysis of EIT illustrates regional lung function and visualizes individual therapeutic effects. Pediatr Pulmonol. 2016;51:1191-1199.
BACKGROUND: Electrical impedance tomography (EIT) delivers information about global and regional ventilation. Linearity of EIT during tidal breathing is known. We investigated the feasibility of EIT during lung function tests in pediatric patients with cystic fibrosis (CF) and healthy controls. METHODS: Eleven CF patients and 11 age-matched controls underwent spirometry and simultaneous EIT. Global EIT results were scaled to spirometric forced vital capacity (FVC). Subsequently, global and regional "EIT-spirometry" was calculated and correlated with clinical findings, radiology, and lung function results before and after bronchospasmolysis (BSL). RESULTS: Spirometry and global EIT results correlated essentially (r2 = 0.71-1.0, P < 0.001). While lung function results were comparable for both groups, EIT demonstrated inhomogeneous ventilation and individual changes after BSL. CONCLUSIONS: EIT changes during forced expiration correlate with lung function parameters, clinical findings, and radiology. Regional analysis of EIT illustrates regional lung function and visualizes individual therapeutic effects. Pediatr Pulmonol. 2016;51:1191-1199.
Authors: Peter A Muller; Jennifer L Mueller; Michelle Mellenthin; Rashmi Murthy; Michael Capps; Brandie D Wagner; Melody Alsaker; Robin Deterding; Scott D Sagel; Jordana Hoppe Journal: Physiol Meas Date: 2018-04-26 Impact factor: 2.833
Authors: Jennifer L Mueller; Peter Muller; Michelle Mellenthin; Rashmi Murthy; Michael Capps; Melody Alsaker; Robin Deterding; Scott D Sagel; Emily DeBoer Journal: Physiol Meas Date: 2018-05-31 Impact factor: 2.833