| Literature DB >> 27127811 |
H Khalili1, P T Khaw, S Brocchini.
Abstract
The Fc-fusion mimetic RpR 2[combining low line] was prepared by disulfide bridging conjugation using PEG in the place of the Fc. RpR 2[combining low line] displayed higher affinity for VEGF than aflibercept. This is caused primarily by a slower dissociation rate, which can prolong a drug at its site of action. RpRs have considerable potential for development as stable, organ specific therapeutics.Entities:
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Year: 2016 PMID： 27127811 DOI： 10.1039/c6bm00077k
Source DB: PubMed Journal: Biomater Sci ISSN： 2047-4830 Impact factor: 6.843