Literature DB >> 27127630

Enhanced User-Control of Small Molecule Drug Release from a Poly(ethylene glycol) Hydrogel via Azobenzene/Cyclodextrin Complex Tethers.

E M Nehls1, A M Rosales2, K S Anseth3.   

Abstract

We present a versatile and facile method to enhance user-control of small molecule drug release from a poly(ethylene glycol)-based hydrogel using the host/guest complex formed between an azobenzene derivative guest and a β-cyclodextrin host. A model drug is formed from a short peptide containing a fluorophore and an azobenzene functional group on one terminus. Upon irradiation with UV light, azobenzene isomerization leads to decreased complex formation and an on-demand acceleratation of the release rate of an entrapped model drug.

Entities:  

Year:  2016        PMID： 27127630      PMCID： PMC4843523          DOI： 10.1039/C5TB02004B

Source DB:  PubMed          Journal:  J Mater Chem B        ISSN： 2050-750X            Impact factor:   6.331


  25 in total

1.  Cyclodextrin-Based Catenanes and Rotaxanes.

Authors:  Sergey A. Nepogodiev; J. Fraser Stoddart
Journal:  Chem Rev       Date:  1998-07-30       Impact factor: 60.622

2.  Cyclodextrin Drug Carrier Systems.

Authors:  Kaneto Uekama; Fumitoshi Hirayama; Tetsumi Irie
Journal:  Chem Rev       Date:  1998-07-30       Impact factor: 60.622

Review 3.  Hydrogels in controlled release formulations: network design and mathematical modeling.

Authors:  Chien-Chi Lin; Andrew T Metters
Journal:  Adv Drug Deliv Rev       Date:  2006-09-22       Impact factor: 15.470

4.  Poly(ethylene glycol) hydrogels formed by conjugate addition with controllable swelling, degradation, and release of pharmaceutically active proteins.

Authors:  Petra van de Wetering; Andrew T Metters; Ronald G Schoenmakers; Jeffrey A Hubbell
Journal:  J Control Release       Date:  2005-02-16       Impact factor: 9.776

5.  Poly(ethylene glycol)-containing hydrogels in drug delivery.

Authors:  N A Peppas; K B Keys; M Torres-Lugo; A M Lowman
Journal:  J Control Release       Date:  1999-11-01       Impact factor: 9.776

Review 6.  PEG hydrogels for the controlled release of biomolecules in regenerative medicine.

Authors:  Chien-Chi Lin; Kristi S Anseth
Journal:  Pharm Res       Date:  2008-12-18       Impact factor: 4.200

7.  Characterization of pH-responsive hydrogels of poly(itaconic acid-g-ethylene glycol) prepared by UV-initiated free radical polymerization as biomaterials for oral delivery of bioactive agents.

Authors:  Tania Betancourt; Juan Pardo; Ken Soo; Nicholas A Peppas
Journal:  J Biomed Mater Res A       Date:  2010-04       Impact factor: 4.396

8.  Cyclodextrin/PEG based hydrogels for multi-drug delivery.

Authors:  Stefano Salmaso; Alessandra Semenzato; Sara Bersani; Pietro Matricardi; Fabio Rossi; Paolo Caliceti
Journal:  Int J Pharm       Date:  2007-05-23       Impact factor: 5.875

9.  Production of heparin-functionalized hydrogels for the development of responsive and controlled growth factor delivery systems.

Authors:  Ting Nie; Aaron Baldwin; Nori Yamaguchi; Kristi L Kiick
Journal:  J Control Release       Date:  2007-05-10       Impact factor: 9.776

10.  Contrast viscosity changes upon photoirradiation for mixtures of poly(acrylic acid)-based alpha-cyclodextrin and azobenzene polymers.

Authors:  Itsuro Tomatsu; Akihito Hashidzume; Akira Harada
Journal:  J Am Chem Soc       Date:  2006-02-22       Impact factor: 15.419
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  5 in total

1.  Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials.

Authors:  Roy Weinstain; Tomáš Slanina; Dnyaneshwar Kand; Petr Klán
Journal:  Chem Rev       Date:  2020-10-30       Impact factor: 60.622

Review 2.  Current Understanding of Hydrogel for Drug Release and Tissue Engineering.

Authors:  Lanjie Lei; Yujing Bai; Xinyun Qin; Juan Liu; Wei Huang; Qizhuang Lv
Journal:  Gels       Date:  2022-05-15

Review 3.  Spatiotemporal hydrogel biomaterials for regenerative medicine.

Authors:  Tobin E Brown; Kristi S Anseth
Journal:  Chem Soc Rev       Date:  2017-10-30       Impact factor: 54.564

4.  Wavelength-Orthogonal Stiffening of Hydrogel Networks with Visible Light.

Authors:  Vinh X Truong; Julian Bachmann; Andreas-Neil Unterreiner; James P Blinco; Christopher Barner-Kowollik
Journal:  Angew Chem Int Ed Engl       Date:  2022-02-15       Impact factor: 16.823

Review 5.  Design and Applications of Photoresponsive Hydrogels.

Authors:  Lei Li; Johannes M Scheiger; Pavel A Levkin
Journal:  Adv Mater       Date:  2019-03-08       Impact factor: 32.086
  5 in total

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