Literature DB >> 27127604

Use of the gamma probe to identify multigland disease in primary hyperparathyroidism.

Kirby Tobin1, Rachel R Ayers1, Mohammad Rajaei1, Rebecca S Sippel1, Courtney J Balentine1, Dawn Elfenbein1, Herb Chen1, David F Schneider1.   

Abstract

AIM: The purpose of this study was to determine threshold gamma probe counts to distinguish single adenoma (SA) from multigland disease (MGD) during radioguided parathyroidectomy.
METHODS: A retrospective analysis of 1656 patients was performed. Ex vivo counts of the first excised gland were taken and recorded as a percentage of background counts.
RESULTS: 69.4% of MGD patients had counts below the 50% threshold. The 50% threshold correctly grouped 72.8% of our cohort. Counts of more than 100% were accurate for grouping SA, with only 6.8% of patients with counts more than 100% having MGD.
CONCLUSIONS: The gamma probe can aid surgeons in deciding to continue neck exploration if MGD is suspected or wait for labs to confirm cure if SA is suspected.

Entities:  

Keywords:  gamma probe; multigland disease; primary hyperparathyroidism; radioguided parathyroidectomy; radionuclide counts; single adenoma; threshold

Year:  2016        PMID： 27127604      PMCID： PMC4844463          DOI： 10.2217/ije.15.27

Source DB:  PubMed          Journal:  Int J Endocr Oncol        ISSN： 2045-0869


  30 in total

1.  Surgery for primary hyperparathyroidism: what is the best approach?

Authors:  Herbert Chen
Journal:  Ann Surg       Date:  2002-11       Impact factor: 12.969

2.  Prospective surgical outcome study of relief of symptoms following surgery in patients with primary hyperparathyroidism.

Authors:  J L Pasieka; L L Parsons
Journal:  World J Surg       Date:  1998-06       Impact factor: 3.352

3.  Unilateral versus bilateral neck exploration for primary hyperparathyroidism: a prospective randomized controlled trial.

Authors:  Anders Bergenfelz; Pia Lindblom; Sten Tibblin; Johan Westerdahl
Journal:  Ann Surg       Date:  2002-11       Impact factor: 12.969

4.  A rising ioPTH level immediately after parathyroid resection: are additional hyperfunctioning glands always present? An application of the Wisconsin Criteria.

Authors:  Mackenzie R Cook; Susan C Pitt; Sarah Schaefer; Rebecca Sippel; Herbert Chen
Journal:  Ann Surg       Date:  2010-06       Impact factor: 12.969

5.  Imaging features of primary hyperparathyroidism.

Authors:  Tsella Lachungpa; Radha Sarawagi; Sunitha Vellathussery Chakkalakkoombil; Annitha Elavarasi Jayamohan
Journal:  BMJ Case Rep       Date:  2014-03-10

6.  Is minimally invasive parathyroidectomy associated with greater recurrence compared to bilateral exploration? Analysis of more than 1,000 cases.

Authors:  David F Schneider; Haggi Mazeh; Rebecca S Sippel; Herbert Chen
Journal:  Surgery       Date:  2012-10-12       Impact factor: 3.982

Review 7.  Asymptomatic primary hyperparathyroidism.

Authors:  B J Harrison; M H Wheeler
Journal:  World J Surg       Date:  1991 Nov-Dec       Impact factor: 3.352

8.  Predicting the success of limited exploration for primary hyperparathyroidism using ultrasound, sestamibi, and intraoperative parathyroid hormone: analysis of 1158 cases.

Authors:  Allan Siperstein; Eren Berber; German F Barbosa; Michael Tsinberg; Andrew B Greene; Jamie Mitchell; Mira Milas
Journal:  Ann Surg       Date:  2008-09       Impact factor: 12.969

9.  The NIH criteria for parathyroidectomy in asymptomatic primary hyperparathyroidism: are they too limited?

Authors:  Monica S Eigelberger; W Keat Cheah; Philip H G Ituarte; Leanne Streja; Quan-Yang Duh; Orlo H Clark
Journal:  Ann Surg       Date:  2004-04       Impact factor: 12.969

10.  Minimal benefit to subsequent intraoperative parathyroid hormone testing after all four glands have been identified.

Authors:  Kamal Ahmed; Amal Alhefdhi; David F Schneider; Kristin A Ojomo; Rebecca S Sippel; Herbert Chen; Haggi Mazeh
Journal:  Ann Surg Oncol       Date:  2013-08-14       Impact factor: 5.344
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.