Alin Adrian Cumpănas1, Anca Maria Cimpean2, Ovidiu Ferician1, Raluca Amalia Ceausu3, Simona Sarb3, Vlad Barbos3, Alice Dema4, Marius Raica3. 1. Department of Ortophedic Surgery, Traumatology and Urology, "Victor Babes" University of Medicine and Pharmacy Timisoara, Timisoara, Romania. 2. Department of Microscopic Morphology/Histology, Angiogenesis Research Center, Timisoara, Romania ancacimpean1972@yahoo.com. 3. Department of Microscopic Morphology/Histology, Angiogenesis Research Center, Timisoara, Romania. 4. Department of Pathology, "Victor Babes" University of Medicine and Pharmacy Timisoara, Timisoara, Romania.
Abstract
BACKGROUND/AIM: Studies developed in the field of platelet-derived growth factors/platelet-derived growth factor receptors (PDGFs/PDGFRs) inhibition have focused on the therapeutic effects on tumor cells, neglecting their potential effects on tumor blood vessels. We herein propose a differential and critic assessment of platelet-derived growth factor B (PDGF-B) and platelet-derived growth factor receptor β (PDGFRβ) in renal cell carcinoma, correlated with the four main vascular patterns previously reported by our team. MATERIALS AND METHODS: PDGF-B and PDGFRβ were evaluated on 50 archival paraffin embedded specimens related to vascular endothelial growth factor (VEGF), its inhibitory isoform VEGF165b and vascular patterns. RESULTS AND CONCLUSION: Our results support the involvement of VEGF165b in the phosphorylation of PDGFRβ with an inhibitory effect on endothelial proliferation and migration. The simultaneous action of PDGF-B/PDGFRβ and VEGF165b on the same type of receptor may explain the resistance to antiangiogenic therapy, which depends on the degree of modulation of PDGFRβ phosphorylation. Copyright
BACKGROUND/AIM: Studies developed in the field of platelet-derived growth factors/platelet-derived growth factor receptors (PDGFs/PDGFRs) inhibition have focused on the therapeutic effects on tumor cells, neglecting their potential effects on tumor blood vessels. We herein propose a differential and critic assessment of platelet-derived growth factor B (PDGF-B) and platelet-derived growth factor receptor β (PDGFRβ) in renal cell carcinoma, correlated with the four main vascular patterns previously reported by our team. MATERIALS AND METHODS:PDGF-B and PDGFRβ were evaluated on 50 archival paraffin embedded specimens related to vascular endothelial growth factor (VEGF), its inhibitory isoform VEGF165b and vascular patterns. RESULTS AND CONCLUSION: Our results support the involvement of VEGF165b in the phosphorylation of PDGFRβ with an inhibitory effect on endothelial proliferation and migration. The simultaneous action of PDGF-B/PDGFRβ and VEGF165b on the same type of receptor may explain the resistance to antiangiogenic therapy, which depends on the degree of modulation of PDGFRβ phosphorylation. Copyright
Authors: Adela Maria Ferician; Ovidiu Catalin Ferician; Andrei Dragos Cumpanas; Patricia Lorena Berzava; Alexandru Nesiu; Ariana Barmayoun; Anca Maria Cimpean Journal: Cancer Genomics Proteomics Date: 2022 Jul-Aug Impact factor: 3.395
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