Karolina Orywal1, Wojciech Jelski2, Michał Zdrodowski3, Maciej Szmitkowski2. 1. Department of Biochemical Diagnostics, Medical University, Bialystok, Poland orywalk@umb.edu.pl. 2. Department of Biochemical Diagnostics, Medical University, Bialystok, Poland. 3. Department of Gynecology, Medical University, Bialystok, Poland.
Abstract
AIM: The aim of this study was to investigate a potential role of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) as tumor markers for cervical cancer. MATERIALS AND METHODS: Blood samples were obtained from 43 women with cervical cancer. Isoenzymes class III, IV of ADH and total ADH activity were measured in the sera by the photometric method and class I, II ADH and ALDH activity by the fluorometric method. RESULTS: The total activity of ADH and ADH I was significantly higher in the serum of patients with cervical cancer than in control groups. The diagnostic sensitivity for ADH I was 61,76%, specificity 65,7%, PPV and NPV were 70 and 62,16% respectively. AUC for ADH I was 0,654 and for total ADH 0,618. CONCLUSION: The results suggest a potential role of ADH I as a marker for cervical cancer. Copyright
AIM: The aim of this study was to investigate a potential role of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) as tumor markers for cervical cancer. MATERIALS AND METHODS: Blood samples were obtained from 43 women with cervical cancer. Isoenzymes class III, IV of ADH and total ADH activity were measured in the sera by the photometric method and class I, II ADH and ALDH activity by the fluorometric method. RESULTS: The total activity of ADH and ADH I was significantly higher in the serum of patients with cervical cancer than in control groups. The diagnostic sensitivity for ADH I was 61,76%, specificity 65,7%, PPV and NPV were 70 and 62,16% respectively. AUC for ADH I was 0,654 and for total ADH 0,618. CONCLUSION: The results suggest a potential role of ADH I as a marker for cervical cancer. Copyright