Literature DB >> 27126091

Identification of bona-fide LRRK2 kinase substrates.

Andrew B West1, Mark R Cookson2.   

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Year:  2016        PMID： 27126091      PMCID： PMC4981516          DOI： 10.1002/mds.26647

Source DB:  PubMed          Journal:  Mov Disord        ISSN： 0885-3185            Impact factor:   10.338


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  5 in total

1.  LRRK2 autophosphorylation enhances its GTPase activity.

Authors:  Zhiyong Liu; James A Mobley; Lawrence J DeLucas; Richard A Kahn; Andrew B West
Journal:  FASEB J       Date:  2015-09-22       Impact factor: 5.191

2.  Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity.

Authors:  Andrew B West; Darren J Moore; Saskia Biskup; Artem Bugayenko; Wanli W Smith; Christopher A Ross; Valina L Dawson; Ted M Dawson
Journal:  Proc Natl Acad Sci U S A       Date:  2005-11-03       Impact factor: 11.205

3.  Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.

Authors:  Zejuan Sheng; Shuo Zhang; Daisy Bustos; Tracy Kleinheinz; Claire E Le Pichon; Sara L Dominguez; Hilda O Solanoy; Jason Drummond; Xiaolin Zhang; Xiao Ding; Fang Cai; Qinghua Song; Xianting Li; Zhenyu Yue; Marcel P van der Brug; Daniel J Burdick; Janet Gunzner-Toste; Huifen Chen; Xingrong Liu; Anthony A Estrada; Zachary K Sweeney; Kimberly Scearce-Levie; John G Moffat; Donald S Kirkpatrick; Haitao Zhu
Journal:  Sci Transl Med       Date:  2012-12-12       Impact factor: 17.956

4.  LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site status.

Authors:  April Reynolds; Elizabeth A Doggett; Steve M Riddle; Connie S Lebakken; R Jeremy Nichols
Journal:  Front Mol Neurosci       Date:  2014-06-24       Impact factor: 5.639

5.  Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

Authors:  Martin Steger; Francesca Tonelli; Genta Ito; Paul Davies; Matthias Trost; Melanie Vetter; Stefanie Wachter; Esben Lorentzen; Graham Duddy; Stephen Wilson; Marco As Baptista; Brian K Fiske; Matthew J Fell; John A Morrow; Alastair D Reith; Dario R Alessi; Matthias Mann
Journal:  Elife       Date:  2016-01-29       Impact factor: 8.140
  5 in total
  8 in total

1.  Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease.

Authors:  Sebastian Schmidt; Malte D Luecken; Dietrich Trümbach; Sina Hembach; Kristina M Niedermeier; Nicole Wenck; Klaus Pflügler; Constantin Stautner; Anika Böttcher; Heiko Lickert; Ciro Ramirez-Suastegui; Ruhel Ahmad; Michael J Ziller; Julia C Fitzgerald; Viktoria Ruf; Wilma D J van de Berg; Allert J Jonker; Thomas Gasser; Beate Winner; Jürgen Winkler; Daniela M Vogt Weisenhorn; Florian Giesert; Fabian J Theis; Wolfgang Wurst
Journal:  Nat Commun       Date:  2022-08-16       Impact factor: 17.694

Review 2.  Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease.

Authors:  Andrew B West
Journal:  Exp Neurol       Date:  2017-07-29       Impact factor: 5.330

3.  LRRK2 binds to the Rab32 subfamily in a GTP-dependent manner via its armadillo domain.

Authors:  Emma McGrath; Dieter Waschbüsch; Brian M Baker; Amir R Khan
Journal:  Small GTPases       Date:  2019-09-25

4.  LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson's Disease Mouse Model.

Authors:  Hien Tran Zhao; Neena John; Vedad Delic; Karli Ikeda-Lee; Aneeza Kim; Andreas Weihofen; Eric E Swayze; Holly B Kordasiewicz; Andrew B West; Laura A Volpicelli-Daley
Journal:  Mol Ther Nucleic Acids       Date:  2017-08-10       Impact factor: 8.886

Review 5.  Targeting for Success: Demonstrating Proof-of-Concept with Mechanistic Early Phase Clinical Pharmacology Studies for Disease-Modification in Neurodegenerative Disorders.

Authors:  Maurits F J M Vissers; Jules A A C Heuberger; Geert Jan Groeneveld
Journal:  Int J Mol Sci       Date:  2021-02-05       Impact factor: 5.923

6.  Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2.

Authors:  Dieter Waschbüsch; Elena Purlyte; Prosenjit Pal; Emma McGrath; Dario R Alessi; Amir R Khan
Journal:  Structure       Date:  2020-02-03       Impact factor: 5.006

Review 7.  Profiling Non-motor Symptoms in Monogenic Parkinson's Disease.

Authors:  Xinyao Liu; Weidong Le
Journal:  Front Aging Neurosci       Date:  2020-10-30       Impact factor: 5.750

8.  Phosphorylation of Rab GTPases in the regulation of membrane trafficking.

Authors:  Dieter Waschbüsch; Amir R Khan
Journal:  Traffic       Date:  2020-10-19       Impact factor: 6.215
  8 in total

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