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Literature DB >> 27125999

Drosha and Dicer: Slicers cut from the same cloth.

Abstract

DROSHA and its partner DGCR8 form a heterotrimeric complex named Microprocessor, which is essential for microRNA biogenesis. A recent study by Kwon et al. in Cell reveals the structure of a DROSHA construct in complex with the C-terminal region of DGCR8, thereby unveiling the topology and interactions between components of the Microprocessor and insights into its 'ruler'-based cleavage activity and function.

Entities: Gene

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Year: 2016 PMID： 27125999 PMCID： PMC4856758 DOI： 10.1038/cr.2016.19

Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617

11 in total

1. Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing.

Authors: Ian Barr; Aaron T Smith; Yanqiu Chen; Rachel Senturia; Judith N Burstyn; Feng Guo
Journal: Proc Natl Acad Sci U S A Date: 2012-01-23 Impact factor: 11.205

2. Structure of Human DROSHA.

Authors: S Chul Kwon; Tuan Anh Nguyen; Yeon-Gil Choi; Myung Hyun Jo; Sungchul Hohng; V Narry Kim; Jae-Sung Woo
Journal: Cell Date: 2015-12-31 Impact factor: 41.582

3. The Microprocessor complex mediates the genesis of microRNAs.

Authors: Richard I Gregory; Kai-Ping Yan; Govindasamy Amuthan; Thimmaiah Chendrimada; Behzad Doratotaj; Neil Cooch; Ramin Shiekhattar
Journal: Nature Date: 2004-11-07 Impact factor: 49.962

4. Structural insight into the mechanism of double-stranded RNA processing by ribonuclease III.

Authors: Jianhua Gan; Joseph E Tropea; Brian P Austin; Donald L Court; David S Waugh; Xinhua Ji
Journal: Cell Date: 2006-01-27 Impact factor: 41.582

5. Structural basis for double-stranded RNA processing by Dicer.

Authors: Ian J Macrae; Kaihong Zhou; Fei Li; Adrian Repic; Angela N Brooks; W Zacheus Cande; Paul D Adams; Jennifer A Doudna
Journal: Science Date: 2006-01-13 Impact factor: 47.728

6. Functional Anatomy of the Human Microprocessor.

Authors: Tuan Anh Nguyen; Myung Hyun Jo; Yeon-Gil Choi; Joha Park; S Chul Kwon; Sungchul Hohng; V Narry Kim; Jae-Sung Woo
Journal: Cell Date: 2015-05-28 Impact factor: 41.582

7. Structural basis for microRNA targeting.

Authors: Nicole T Schirle; Jessica Sheu-Gruttadauria; Ian J MacRae
Journal: Science Date: 2014-10-31 Impact factor: 47.728

8. Processing of primary microRNAs by the Microprocessor complex.

Authors: Ahmet M Denli; Bastiaan B J Tops; Ronald H A Plasterk; René F Ketting; Gregory J Hannon
Journal: Nature Date: 2004-11-07 Impact factor: 49.962

9. The nuclear RNase III Drosha initiates microRNA processing.

Authors: Yoontae Lee; Chiyoung Ahn; Jinju Han; Hyounjeong Choi; Jaekwang Kim; Jeongbin Yim; Junho Lee; Patrick Provost; Olof Rådmark; Sunyoung Kim; V Narry Kim
Journal: Nature Date: 2003-09-25 Impact factor: 49.962

10. The Menu of Features that Define Primary MicroRNAs and Enable De Novo Design of MicroRNA Genes.

Authors: Wenwen Fang; David P Bartel
Journal: Mol Cell Date: 2015-09-24 Impact factor: 17.970

8 in total

1. Phylogenomics of the Epigenetic Toolkit Reveals Punctate Retention of Genes across Eukaryotes.

Authors: Agnes K M Weiner; Mario A Cerón-Romero; Ying Yan; Laura A Katz
Journal: Genome Biol Evol Date: 2020-12-06 Impact factor: 3.416

Review 2. piRNA Biogenesis in Drosophila melanogaster.

Authors: Xiawei Huang; Katalin Fejes Tóth; Alexei A Aravin
Journal: Trends Genet Date: 2017-09-27 Impact factor: 11.639

Review 3. Target acquired: transcriptional regulators as drug targets for protozoan parasites.

Authors: H A Walters; L A Temesvari
Journal: Int J Parasitol Date: 2021-03-13 Impact factor: 4.330

4. An Evolutionarily Conserved AU-Rich Element in the 3' Untranslated Region of a Transcript Misannotated as a Long Noncoding RNA Regulates RNA Stability.

Authors: Emily A Dangelmaier; Xiao Ling Li; Corrine Corrina R Hartford; Julianna C King; Meira S Zibitt; Raj Chari; Ioannis Grammatikakis; Ashish Lal
Journal: Mol Cell Biol Date: 2022-03-11 Impact factor: 5.069

Review 5. Autophagy-Regulating microRNAs and Cancer.

Authors: Devrim Gozuacik; Yunus Akkoc; Deniz Gulfem Ozturk; Muhammed Kocak
Journal: Front Oncol Date: 2017-04-18 Impact factor: 6.244

Review 6. MicroRNAs and Metabolism: Revisiting the Warburg Effect with Emphasis on Epigenetic Background and Clinical Applications.

Authors: Zsuzsanna Gaál
Journal: Biomolecules Date: 2021-10-17

7. Zucchini-dependent piRNA processing is triggered by recruitment to the cytoplasmic processing machinery.

Authors: Alicia K Rogers; Kathy Situ; Edward M Perkins; Katalin Fejes Toth
Journal: Genes Dev Date: 2017-10-11 Impact factor: 11.361

8. Dynamical comparison between Drosha and Dicer reveals functional motion similarities and dissimilarities.

Authors: Rotem Aharoni; Dror Tobi
Journal: PLoS One Date: 2019-12-10 Impact factor: 3.240

8 in total