Mats Brännström1, Hans Bokström2, Pernilla Dahm-Kähler2, Cesar Diaz-Garcia3, Jana Ekberg4, Anders Enskog5, Henrik Hagberg6, Liza Johannesson2, Niclas Kvarnström4, Johan Mölne7, Michael Olausson4, Jan I Olofsson8, Kenny Rodriguez-Wallberg9. 1. Department of Obstetrics and Gynecology, Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden; Stockholm IVF, Stockholm, Sweden. Electronic address: mats.brannstrom@obgyn.gu.se. 2. Department of Obstetrics and Gynecology, Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden. 3. Department of Obstetrics and Gynecology, La Fe Hospital, University of Valencia, Valencia, Spain. 4. Department of Transplantation, Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden. 5. Department of Anesthesiology and Intensive Care, Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden. 6. Department of Obstetrics and Gynecology, Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden; Center for the Developing Brain, Division of Imagining Sciences and Biomedical Engineering, King's College London, London, United Kingdom. 7. Department of Clinical Pathology and Genetics, Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden. 8. Reproductive Medicine, Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, Sweden; Division of Obstetrics and Gynecology, Department of Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden. 9. Reproductive Medicine, Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, Sweden; Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
Abstract
OBJECTIVE: To determine whether a uterus from the mother of a woman with absolute uterine factor infertility can be transplanted to daughter and carry a pregnancy with delivery of a healthy child. DESIGN: Part of an observational study. SETTING: University teaching hospital. PATIENT(S): Twenty eight-year-old woman with uterine agenesis, her male partner, and her 50-year-old mother. INTERVENTION(S): In vitro fertilization with embryo cryopreservation before live donor uterus transplantation (UTx). Induction immunosuppression. Embryo transfer 12 months after UTx, pregnancy controls, delivery, and hysterectomy. MAIN OUTCOME MEASURE(S): Results of IVF-ET, parameters of pregnancy/birth, and surgical data of transplantation/cesarean section/hysterectomy. RESULT(S): Two IVF cycles before UTx resulted in 10 cryopreserved embryos. Donor surgery included hysterectomy with vascular pedicles of uterine vessels and proximal vessels up to and including parts of internal iliacs. Recipient surgery was by bilateral vascular connections to external iliacs, vaginal-vaginal anastomosis, and uterine fixation. Pregnancy occurred at the first single ET, and the pregnancy proceeded uneventfully until gestational week 34, when the patient developed cholestasis with intense pruritus. Cesarean section was performed at 34+6, with delivery of a healthy boy (weight 2,335 g). Hysterectomy was performed 3.5 months after delivery. The weight of the healthy child at 12 months was 9.3 kg. Grandmother (uterus donor) and mother are in good health 3 years after UTx. CONCLUSION(S): This is the first report of a live birth after mother-to-daughter UTx, and it also represents the second birth ever after human UTx. CLINICAL TRIAL REGISTRATION: NCT01844362.
OBJECTIVE: To determine whether a uterus from the mother of a woman with absolute uterine factor infertility can be transplanted to daughter and carry a pregnancy with delivery of a healthy child. DESIGN: Part of an observational study. SETTING: University teaching hospital. PATIENT(S): Twenty eight-year-old woman with uterine agenesis, her male partner, and her 50-year-old mother. INTERVENTION(S): In vitro fertilization with embryo cryopreservation before live donor uterus transplantation (UTx). Induction immunosuppression. Embryo transfer 12 months after UTx, pregnancy controls, delivery, and hysterectomy. MAIN OUTCOME MEASURE(S): Results of IVF-ET, parameters of pregnancy/birth, and surgical data of transplantation/cesarean section/hysterectomy. RESULT(S): Two IVF cycles before UTx resulted in 10 cryopreserved embryos. Donor surgery included hysterectomy with vascular pedicles of uterine vessels and proximal vessels up to and including parts of internal iliacs. Recipient surgery was by bilateral vascular connections to external iliacs, vaginal-vaginal anastomosis, and uterine fixation. Pregnancy occurred at the first single ET, and the pregnancy proceeded uneventfully until gestational week 34, when the patient developed cholestasis with intense pruritus. Cesarean section was performed at 34+6, with delivery of a healthy boy (weight 2,335 g). Hysterectomy was performed 3.5 months after delivery. The weight of the healthy child at 12 months was 9.3 kg. Grandmother (uterus donor) and mother are in good health 3 years after UTx. CONCLUSION(S): This is the first report of a live birth after mother-to-daughter UTx, and it also represents the second birth ever after human UTx. CLINICAL TRIAL REGISTRATION: NCT01844362.
Authors: Arvind Manikantan Padma; Laura Carrière; Frida Krokström Karlsson; Edina Sehic; Sara Bandstein; Tom Tristan Tiemann; Mihai Oltean; Min Jong Song; Mats Brännström; Mats Hellström Journal: NPJ Regen Med Date: 2021-05-21