Literature DB >> 27125199

The Role of Steroid Receptor Coactivators in Hormone Dependent Cancers and Their Potential as Therapeutic Targets.

Lei Wang1, David M Lonard1, Bert W O'Malley2.   

Abstract

Steroid receptor coactivator (SRC) family members (SRC-1, SRC-2, SRC-3) interact with nuclear receptors (NRs) and many transcription factors to enhance target gene transcription. Deregulation of SRCs is widely implicated in NR mediated diseases, especially hormone dependent cancers. By integrating steroid hormone signaling and growth factor pathways, SRC proteins exert multiple modes of oncogenic regulation in cancers and represent emerging targets for cancer therapeutics. Recent work has identified SRC-targeting agents that show promise in blocking tumor growth in vitro and in vivo, and have the potential to function as powerful and broadly encompassing treatments for different cancers.

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Year:  2016        PMID： 27125199      PMCID： PMC4930410          DOI： 10.1007/s12672-016-0261-6

Source DB:  PubMed          Journal:  Horm Cancer        ISSN： 1868-8497            Impact factor:   3.869


  77 in total

1.  Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.

Authors:  B G Rowan; N L Weigel; B W O'Malley
Journal:  J Biol Chem       Date:  2000-02-11       Impact factor: 5.157

2.  SRC-1 and TIF2 control energy balance between white and brown adipose tissues.

Authors:  Frédéric Picard; Martine Géhin; Jean- Sébastien Annicotte; Stéphane Rocchi; Marie-France Champy; Bert W O'Malley; Pierre Chambon; Johan Auwerx
Journal:  Cell       Date:  2002-12-27       Impact factor: 41.582

Review 3.  Androgen receptor coactivators and prostate cancer.

Authors:  Irina U Agoulnik; Nancy L Weigel
Journal:  Adv Exp Med Biol       Date:  2008       Impact factor: 2.622

4.  Involvement of nuclear receptor coactivator SRC-1 in estrogen-dependent cell growth of MCF-7 cells.

Authors:  H Tai; N Kubota; S Kato
Journal:  Biochem Biophys Res Commun       Date:  2000-01-07       Impact factor: 3.575

5.  Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen-induced mammary tumorigenesis.

Authors:  Shao-Qing Kuang; Lan Liao; Shu Wang; Daniel Medina; Bert W O'Malley; Jianming Xu
Journal:  Cancer Res       Date:  2005-09-01       Impact factor: 12.701

6.  SRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migration.

Authors:  Weiwen Long; Ping Yi; Larbi Amazit; Heather L LaMarca; Felicity Ashcroft; Rakesh Kumar; Michael A Mancini; Sophia Y Tsai; Ming-Jer Tsai; Bert W O'Malley
Journal:  Mol Cell       Date:  2010-02-12       Impact factor: 17.970

Review 7.  Steroid receptor coactivator (SRC) family: masters of systems biology.

Authors:  Brian York; Bert W O'Malley
Journal:  J Biol Chem       Date:  2010-10-18       Impact factor: 5.157

Review 8.  Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family.

Authors:  Jianming Xu; Ray-Chang Wu; Bert W O'Malley
Journal:  Nat Rev Cancer       Date:  2009-09       Impact factor: 60.716

9.  Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation.

Authors:  Shu Wang; Yuhui Yuan; Lan Liao; Shao-Qing Kuang; Jean Ching-Yi Tien; Bert W O'Malley; Jianming Xu
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-24       Impact factor: 11.205

10.  Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease.

Authors:  Atul R Chopra; Jean-Francois Louet; Pradip Saha; Jie An; Franco Demayo; Jianming Xu; Brian York; Saul Karpen; Milton Finegold; David Moore; Lawrence Chan; Christopher B Newgard; Bert W O'Malley
Journal:  Science       Date:  2008-11-28       Impact factor: 47.728
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  11 in total

Review 1.  Steroids and the brain: 50years of research, conceptual shifts and the ascent of non-classical and membrane-initiated actions.

Authors:  Jacques Balthazart; Elena Choleris; Luke Remage-Healey
Journal:  Horm Behav       Date:  2018-01-12       Impact factor: 3.587

2.  Steroid receptor coactivator-3 as a target for anaplastic thyroid cancer.

Authors:  Woo Kyung Lee; Won Gu Kim; Laura Fozzatti; Sunmi Park; Li Zhao; Mark C Willingham; David Lonard; Bert W O'Malley; Sheue-Yann Cheng
Journal:  Endocr Relat Cancer       Date:  2020-04       Impact factor: 5.678

Review 3.  Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions.

Authors:  Petr Pavek
Journal:  Front Pharmacol       Date:  2016-11-25       Impact factor: 5.810

4.  Coregulator profiling of the glucocorticoid receptor in lymphoid malignancies.

Authors:  Dorien Clarisse; Jonathan Thommis; Karlien Van Wesemael; René Houtman; Dariusz Ratman; Jan Tavernier; Fritz Offner; Ilse Beck; Karolien De Bosscher
Journal:  Oncotarget       Date:  2017-11-30

5.  Network analysis of SRC-1 reveals a novel transcription factor hub which regulates endocrine resistant breast cancer.

Authors:  Alacoque L Browne; Sara Charmsaz; Damir Varešlija; Ailis Fagan; Nicola Cosgrove; Sinéad Cocchiglia; Siobhan Purcell; Elspeth Ward; Fiona Bane; Lance Hudson; Arnold D Hill; Jason S Carroll; Aisling M Redmond; Leonie S Young
Journal:  Oncogene       Date:  2018-01-25       Impact factor: 9.867

6.  A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells.

Authors:  Yosi Gilad; Yossi Eliaz; Yang Yu; Adam M Dean; San Jung Han; Li Qin; Bert W O'Malley; David M Lonard
Journal:  Commun Biol       Date:  2021-03-25

7.  Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype.

Authors:  Damir Varešlija; Elspeth Ward; Siobhan P Purcell; Nicola S Cosgrove; Sinéad Cocchiglia; Philip J O'Halloran; Sara Charmsaz; Fiona T Bane; Francesca M Brett; Michael Farrell; Jane Cryan; Alan Beausang; Lance Hudson; Arran K Turnbul; J Michael Dixon; Arnold D K Hill; Nolan Priedigkeit; Steffi Oesterreich; Adrian V Lee; Andrew H Sims; Aisling M Redmond; Jason S Carroll; Leonie S Young
Journal:  Oncogene       Date:  2021-01-08       Impact factor: 9.867

Review 8.  The Nuclear Receptor PXR in Chronic Liver Disease.

Authors:  Katia Sayaf; Ilaria Zanotto; Francesco Paolo Russo; Daniela Gabbia; Sara De Martin
Journal:  Cells       Date:  2021-12-27       Impact factor: 6.600

9.  SRC-2 Coactivator: a role in human metabolic evolution and disease.

Authors:  Bert W O'Malley
Journal:  Mol Med       Date:  2020-05-14       Impact factor: 6.354

10.  Androgen up-regulation of Twist1 gene expression is mediated by ETV1.

Authors:  Prabesh Khatiwada; Archana Kannan; Mamata Malla; Megan Dreier; Lirim Shemshedini
Journal:  PeerJ       Date:  2020-04-09       Impact factor: 2.984
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