Literature DB >> 27125018

[Anti-Inflammatory Activity of the Polypeptide of the Sea Anemone, Heteractis crispa].

O V Sintsova, M M Monastyrnaya, E A Pislyagin, E S Menchinskaya, E V Leychenko, D L Aminin, E P Kozlovskaya.   

Abstract

The anti-inflammatory effect of the recombinant polypeptide HCGS 1.20, a Kunitz-type serine protease inhibitor of the sea anemone Heteractis crispa, was investigated. It was shown that the polypeptide inhibits the increase of the concentration of calcium ions in mouse bone marrow derived macrophages elicited by histamine, and reduces the content of NO in lipopolysaccharide stimulated macrophages. A presumable mechanism of anti-inflammatory action of the polypeptide was being discussed.

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Year:  2015        PMID： 27125018     DOI： 10.1134/s106816201506014x

Source DB:  PubMed          Journal:  Bioorg Khim        ISSN： 0132-3423


  5 in total

1.  Kunitz-Type Peptides from Sea Anemones Protect Neuronal Cells against Parkinson's Disease Inductors via Inhibition of ROS Production and ATP-Induced P2X7 Receptor Activation.

Authors:  Aleksandra Kvetkina; Evgeny Pislyagin; Ekaterina Menchinskaya; Ekaterina Yurchenko; Rimma Kalina; Sergei Kozlovskiy; Leonid Kaluzhskiy; Alexander Menshov; Natalia Kim; Steve Peigneur; Jan Tytgat; Alexis Ivanov; Naira Ayvazyan; Elena Leychenko; Dmitry Aminin
Journal:  Int J Mol Sci       Date:  2022-05-04       Impact factor: 6.208

Review 2.  A Review of Toxins from Cnidaria.

Authors:  Isabella D'Ambra; Chiara Lauritano
Journal:  Mar Drugs       Date:  2020-10-06       Impact factor: 5.118

3.  Cereus sinensis Polysaccharide Alleviates Antibiotic-Associated Diarrhea Based on Modulating the Gut Microbiota in C57BL/6 Mice.

Authors:  Mingxiao Cui; Yu Wang; Jeevithan Elango; Junwen Wu; Kehai Liu; Yinzhe Jin
Journal:  Front Nutr       Date:  2021-12-13

4.  Sea Anemone Kunitz-Type Peptides Demonstrate Neuroprotective Activity in the 6-Hydroxydopamine Induced Neurotoxicity Model.

Authors:  Oksana Sintsova; Irina Gladkikh; Margarita Monastyrnaya; Valentin Tabakmakher; Ekaterina Yurchenko; Ekaterina Menchinskaya; Evgeny Pislyagin; Yaroslav Andreev; Sergey Kozlov; Steve Peigneur; Jan Tytgat; Dmitry Aminin; Emma Kozlovskaya; Elena Leychenko
Journal:  Biomedicines       Date:  2021-03-10

5.  Deep-Sea Anemones Are Prospective Source of New Antimicrobial and Cytotoxic Compounds.

Authors:  Aleksandra Kvetkina; Elena Kostina; Irina Gladkikh; Victoria Chausova; Ekaterina Yurchenko; Irina Bakunina; Mikhail Pivkin; Stanislav Anastyuk; Roman Popov; Margarita Monastyrnaya; Emma Kozlovskaya; Marina Isaeva; Pavel Dmitrenok; Elena Leychenko
Journal:  Mar Drugs       Date:  2021-11-24       Impact factor: 5.118
  5 in total

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