Literature DB >> 27122816

Mesenchymal Stem Cell Derived Exosomes: A New Hope for the Treatment of Cardiovascular Disease?

Chen-Rong Tsao1, Mau-Fang Liao2, Min-Hsiung Wang3, Chien-Ming Cheng2, Chu-Huang Chen4.   

Abstract

UNLABELLED: Cardiovascular disease is a major target for numerous experimental stem (progenitor) cell-based therapies. Mesenchymal stem cells (MSCs) from different sources confer regenerative effects in animal models of cardiovascular disease. Some of these investigations have proceeded into phase I and II clinical trials for limb ischemia, heart failure, and acute myocardial infarction. The rationale for MSC therapy is increasingly recognized on a secretion (paracrine) rather than differentiation mechanism. Recently, several groups have demonstrated that the "exosome" is a secreted agent mediating MSC therapeutic efficacy. Unlike cell therapy, exosomes have no risk of aneuploidy, and a lower rate of immune rejection following allogeneic administration. In this short review, we will focus on the potential of using this novel therapeutic modality for the treatment of cardiovascular disease, particularly acute myocardial infarction. KEY WORDS: Cardiovascular disease; Exosome; Mesenchymal.

Entities:  

Year:  2014        PMID： 27122816      PMCID： PMC4834956     

Source DB:  PubMed          Journal:  Acta Cardiol Sin        ISSN： 1011-6842            Impact factor:   2.672


  35 in total

1.  Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms.

Authors:  T Kinnaird; E Stabile; M S Burnett; C W Lee; S Barr; S Fuchs; S E Epstein
Journal:  Circ Res       Date:  2004-01-22       Impact factor: 17.367

Review 2.  Exosomes as biomarker treasure chests for prostate cancer.

Authors:  Diederick Duijvesz; Theo Luider; Chris H Bangma; Guido Jenster
Journal:  Eur Urol       Date:  2010-12-29       Impact factor: 20.096

3.  Intracoronary transplantation of autologous bone marrow mesenchymal stem cells for ischemic cardiomyopathy due to isolated chronic occluded left anterior descending artery.

Authors:  Shaoliang Chen; Zhizhong Liu; Nailiang Tian; Junjie Zhang; Fei Yei; Baoxian Duan; Zhongsheng Zhu; Song Lin; Tak W Kwan
Journal:  J Invasive Cardiol       Date:  2006-11       Impact factor: 2.022

Review 4.  Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views.

Authors:  Donald G Phinney; Darwin J Prockop
Journal:  Stem Cells       Date:  2007-09-27       Impact factor: 6.277

5.  Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury.

Authors:  Ruenn Chai Lai; Fatih Arslan; May May Lee; Newman Siu Kwan Sze; Andre Choo; Tian Sheng Chen; Manuel Salto-Tellez; Leo Timmers; Chuen Neng Lee; Reida Menshawe El Oakley; Gerard Pasterkamp; Dominique P V de Kleijn; Sai Kiang Lim
Journal:  Stem Cell Res       Date:  2010-01-04       Impact factor: 2.020

Review 6.  Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease.

Authors:  Ruenn Chai Lai; Tian Sheng Chen; Sai Kiang Lim
Journal:  Regen Med       Date:  2011-07       Impact factor: 3.806

7.  Intramyocardial and intracoronary autologous bone marrow-derived mesenchymal stromal cell treatment in chronic severe dilated cardiomyopathy.

Authors:  Sze-Piaw Chin; Alfred C Poey; Chee-Yin Wong; Sau-Kong Chang; Chiang-Soo Tan; Mei-Theng Ng; Kee-Hock Chew; Kai-Huat Lam; Soon-Keng Cheong
Journal:  Cytotherapy       Date:  2011-04-28       Impact factor: 5.414

8.  A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction.

Authors:  Joshua M Hare; Jay H Traverse; Timothy D Henry; Nabil Dib; Robert K Strumpf; Steven P Schulman; Gary Gerstenblith; Anthony N DeMaria; Ali E Denktas; Roger S Gammon; James B Hermiller; Mark A Reisman; Gary L Schaer; Warren Sherman
Journal:  J Am Coll Cardiol       Date:  2009-12-08       Impact factor: 24.094

9.  Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL-1 alpha.

Authors:  S E Haynesworth; M A Baber; A I Caplan
Journal:  J Cell Physiol       Date:  1996-03       Impact factor: 6.384

Review 10.  Exosomes derived from mesenchymal stem cells.

Authors:  Bo Yu; Xiaomin Zhang; Xiaorong Li
Journal:  Int J Mol Sci       Date:  2014-03-07       Impact factor: 5.923
View more
  11 in total

Review 1.  Stem cell-derived exosomes: A promising strategy for fracture healing.

Authors:  Zi-Chen Hao; Jun Lu; Shan-Zheng Wang; Hao Wu; Yun-Tong Zhang; Shuo-Gui Xu
Journal:  Cell Prolif       Date:  2017-07-25       Impact factor: 6.831

2.  Knockdown of ubiquitin D inhibits adipogenesis during the differentiation of porcine intramuscular and subcutaneous preadipocytes.

Authors:  Chen Zhao; Xiangping Yao; Xiaochang Chen; Wenjing Wu; Fengxue Xi; Gongshe Yang; Taiyong Yu
Journal:  Cell Prolif       Date:  2017-11-23       Impact factor: 6.831

3.  Bioinspired artificial exosomes based on lipid nanoparticles carrying let-7b-5p promote angiogenesis in vitro and in vivo.

Authors:  Sezin Aday; Inbal Hazan-Halevy; Aranzazu Chamorro-Jorganes; Maryam Anwar; Meir Goldsmith; Nicholas Beazley-Long; Susmita Sahoo; Navneet Dogra; Walid Sweaad; Francesco Catapano; Sho Ozaki-Tan; Gianni D Angelini; Paolo Madeddu; Andrew V Benest; Dan Peer; Costanza Emanueli
Journal:  Mol Ther       Date:  2021-03-18       Impact factor: 12.910

Review 4.  Placenta-derived exosomes: potential biomarkers of preeclampsia.

Authors:  Preenan Pillay; Kogi Moodley; Jagidesa Moodley; Irene Mackraj
Journal:  Int J Nanomedicine       Date:  2017-10-31

5.  Immunosuppressive Effect of Exosomes from Mesenchymal Stromal Cells in Defined Medium on Experimental Colitis.

Authors:  Zhi Jie Ma; Yun Hong Wang; Zhi Gang Li; Ying Wang; Bing Yao Li; Hui Yan Kang; Xiao Yun Wu
Journal:  Int J Stem Cells       Date:  2019-11-30       Impact factor: 2.500

Review 6.  Exosomes as Biomarkers for Female Reproductive Diseases Diagnosis and Therapy.

Authors:  Sahar Esfandyari; Hoda Elkafas; Rishi Man Chugh; Hang-Soo Park; Antonia Navarro; Ayman Al-Hendy
Journal:  Int J Mol Sci       Date:  2021-02-22       Impact factor: 5.923

7.  Exosomes Derived from miR-146a-5p-Enriched Mesenchymal Stem Cells Protect the Cardiomyocytes and Myocardial Tissues in the Polymicrobial Sepsis through Regulating MYBL1.

Authors:  Chun Liu; Jianhua Xue; Bo Xu; Aixian Zhang; Lili Qin; Jiajia Liu; Yang Yang
Journal:  Stem Cells Int       Date:  2021-10-15       Impact factor: 5.443

Review 8.  Extracellular Vesicles in Cardiovascular Theranostics.

Authors:  Yihua Bei; Saumya Das; Rodosthenis S Rodosthenous; Paul Holvoet; Maarten Vanhaverbeke; Marta Chagas Monteiro; Valter Vinicius Silva Monteiro; Jana Radosinska; Monika Bartekova; Felix Jansen; Qian Li; Johnson Rajasingh; Junjie Xiao
Journal:  Theranostics       Date:  2017-09-26       Impact factor: 11.556

9.  BMMSC-sEV-derived miR-328a-3p promotes ECM remodeling of damaged urethral sphincters via the Sirt7/TGFβ signaling pathway.

Authors:  Hanke Zhang; Jiayu Huang; Jiaying Liu; Yanhui Li; Ying Gao
Journal:  Stem Cell Res Ther       Date:  2020-07-16       Impact factor: 6.832

10.  Exosomes derived from human umbilical cord mesenchymal stem cells inhibit vein graft intimal hyperplasia and accelerate reendothelialization by enhancing endothelial function.

Authors:  Qingxi Qu; Yingxin Pang; Chunmei Zhang; Linghong Liu; Yanwen Bi
Journal:  Stem Cell Res Ther       Date:  2020-03-23       Impact factor: 6.832
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.