De-Hua He1, Liang-Min Zhang2, Li-Ming Lin3, Ruo-Bing Ning4, Hua-Jun Wang5, Chang-Sheng Xu5, Jin-Xiu Lin4. 1. Department of Cardiology, First Affiliated Hospital of Xiamen University; ; Department of Cardiology, First Clinical Medical College of Fujian Medical University, Fujian; 2. Department of Cardiology, People's Hospital of Ningdu County, Jiangxi; 3. Department of Cardiology, Affiliated Hospital of Putian College; 4. Department of Cardiology, First Clinical Medical College of Fujian Medical University, Fujian; 5. Fujian Institute of Hypertension, Fujian, China.
Abstract
BACKGROUND: The purpose of this study was to evaluate the effects of prehypertensive losartan and amlodipine administration on left ventricular (LV) remodeling and function in spontaneously hypertensive rats-stroke prone (SHRSP). METHODS: Spontaneously hypertensive rats-stroke prone were prehypertensively administered losartan, amlodipine, or vehicle. Wistar-Kyoto rats were used as a control. Blood pressure of the rats was determined by tail-cuff method, and LV structure and function were measured by echocardiography and LV cannulation. Collagen volume fraction was analyzed by picrosirius red staining. Protein expressions of brain natriuretic peptide (BNP) and angiotensin II type 1 (AT1R) and type 2 (AT2R) receptors were determined by use of the Western blotting method. RESULTS: Although both drugs downregulated BNP protein expression, the LV remodeling and function were more improved with losartan than with amlodipine treatment. Losartan upregulated AT1R and downregulated AT2R protein expression. CONCLUSIONS: Both drugs inhibited LV remodeling and improved LV function in prehypertensively treated SHRSP. Losartan provided better continued heart protection, potentially due to its persistent inhibition of AT1R and activation of AT2R in the myocardium. KEY WORDS: Amlodipine; Blood pressure; Heart; Losartan; Prehypertension.
BACKGROUND: The purpose of this study was to evaluate the effects of prehypertensive losartan and amlodipine administration on left ventricular (LV) remodeling and function in spontaneously hypertensiverats-stroke prone (SHRSP). METHODS: Spontaneously hypertensiverats-stroke prone were prehypertensively administered losartan, amlodipine, or vehicle. Wistar-Kyoto rats were used as a control. Blood pressure of the rats was determined by tail-cuff method, and LV structure and function were measured by echocardiography and LV cannulation. Collagen volume fraction was analyzed by picrosirius red staining. Protein expressions of brain natriuretic peptide (BNP) and angiotensin II type 1 (AT1R) and type 2 (AT2R) receptors were determined by use of the Western blotting method. RESULTS: Although both drugs downregulated BNP protein expression, the LV remodeling and function were more improved with losartan than with amlodipine treatment. Losartan upregulated AT1R and downregulated AT2R protein expression. CONCLUSIONS: Both drugs inhibited LV remodeling and improved LV function in prehypertensively treated SHRSP. Losartan provided better continued heart protection, potentially due to its persistent inhibition of AT1R and activation of AT2R in the myocardium. KEY WORDS: Amlodipine; Blood pressure; Heart; Losartan; Prehypertension.
Authors: Judith Hsia; Karen L Margolis; Charles B Eaton; Nanette K Wenger; Matthew Allison; LieLing Wu; Andrea Z LaCroix; Henry R Black Journal: Circulation Date: 2007-02-20 Impact factor: 29.690
Authors: Aram V Chobanian; George L Bakris; Henry R Black; William C Cushman; Lee A Green; Joseph L Izzo; Daniel W Jones; Barry J Materson; Suzanne Oparil; Jackson T Wright; Edward J Roccella Journal: Hypertension Date: 2003-12-01 Impact factor: 10.190
Authors: Vitantonio Di Bello; Enrica Talini; Giulia Dell'Omo; Cristina Giannini; Maria Grazia Delle Donne; Maria Laura Canale; Carmela Nardi; Caterina Palagi; Frank Lloyd Dini; Giuseppe Penno; Stefano Del Prato; Mario Marzilli; Roberto Pedrinelli Journal: Am J Hypertens Date: 2009-12-31 Impact factor: 2.689