Ming-Tai Lin1, Chin-Hao Chang2, Wen-Chin Hsieh1, Chi-En Chang1, Ya-Mei Chang1, Yung-Chuan Chen3, Jui-Yu Hsu4, Yi-Ling Huang5, Juine-Yih Ma6, Li-Chuan Sun7, Chi-Sen Wu8, Su-Zen Yeh6, Wei-Quan Fang9, Chun-An Chen1, Shuenn-Nan Chiu1, Chun-Wei Lu1, Jou-Kou Wang1, Mei-Hwan Wu1. 1. Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University; 2. Department of Medical Research, National Taiwan University Hospital; 3. Department of Pediatrics, Cathay General Hospital; 4. Department of Pediatrics, Buddhist Tzu-Chi General Hospital, Taipei Branch; 5. Department of Pediatrics, Wan Fang Hospital, Taipei Medical University; 6. Department of Pediatrics, Far-East Memorial Hospital; 7. Department of Pediatrics, Cardinal Tien Hospital; 8. Department of Pediatrics, Taipei City Hospital; 9. National Translational Medicine and Clinical Trial Resource Center, Taipei, Taiwan.
Abstract
BACKGROUND: The measurements of coronary diameters, usually obtained by 2-dimentsional echocardiography, play important roles oin the management and follow-up of Kawasaki disease (KD). However, in Taiwan, domestic normgrams and a Z-score calculator for coronary artery diameters are still not available. METHODS: Echocardiography was performed on 412 healthy children younger than 6 years of age. The appropriate exponential regression model was fitted to correspond with body surface area (BSA). The computed Z-scores of all subjects were also tested for normal distribution. RESULTS: Using the model ln (measurement) = β1 + β2 × ln (BSA), the adjusted R(2) values were 0.611 and 0.484 for the models of the left main coronary artery (LMCA) and the right (RCA), respectively. Analysis of computed Z-score distribution showed acceptable goodness of fit for a normal distribution [p = 0.90 (LMCA); p = 0.17 (RCA)]. CONCLUSIONS: We have established reference ranges for the coronary artery diameters in Taiwanese children younger than 6 years of age. The regression equations and Z-score calculators for the LMCA and RCA provide an objective determination of coronary dilatation in a large population, which is important for the care and medical management of KD patients in Taiwan. KEY WORDS: Coronary diameter; Kawasaki disease; Taiwan; Z-score.
BACKGROUND: The measurements of coronary diameters, usually obtained by 2-dimentsional echocardiography, play important roles oin the management and follow-up of Kawasaki disease (KD). However, in Taiwan, domestic normgrams and a Z-score calculator for coronary artery diameters are still not available. METHODS: Echocardiography was performed on 412 healthy children younger than 6 years of age. The appropriate exponential regression model was fitted to correspond with body surface area (BSA). The computed Z-scores of all subjects were also tested for normal distribution. RESULTS: Using the model ln (measurement) = β1 + β2 × ln (BSA), the adjusted R(2) values were 0.611 and 0.484 for the models of the left main coronary artery (LMCA) and the right (RCA), respectively. Analysis of computed Z-score distribution showed acceptable goodness of fit for a normal distribution [p = 0.90 (LMCA); p = 0.17 (RCA)]. CONCLUSIONS: We have established reference ranges for the coronary artery diameters in Taiwanese children younger than 6 years of age. The regression equations and Z-score calculators for the LMCA and RCA provide an objective determination of coronary dilatation in a large population, which is important for the care and medical management of KDpatients in Taiwan. KEY WORDS: Coronary diameter; Kawasaki disease; Taiwan; Z-score.
Authors: Jane W Newburger; Masato Takahashi; Michael A Gerber; Michael H Gewitz; Lloyd Y Tani; Jane C Burns; Stanford T Shulman; Ann F Bolger; Patricia Ferrieri; Robert S Baltimore; Walter R Wilson; Larry M Baddour; Matthew E Levison; Thomas J Pallasch; Donald A Falace; Kathryn A Taubert Journal: Pediatrics Date: 2004-12 Impact factor: 7.124
Authors: Tsung-Hsun Yang; Yan-Yuh Lee; Lin-Yi Wang; Ta-Chih Chang; Ling-Sai Chang; Ho-Chang Kuo Journal: Int J Environ Res Public Health Date: 2020-11-11 Impact factor: 3.390