Hung-Yu Yang1, Jen-Hung Huang2, Yung-Kuo Lin3, Chien-Yeh Hsu4, Shih-Ann Chen5, Yi-Jen Chen3. 1. Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; ; Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei, Taiwan; 2. Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; 3. Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; ; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; 4. Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei, Taiwan; 5. Division of Cardiology and Cardiovascular Research Center, Taipei Veterans General Hospital, Taipei, Taiwan.
Abstract
BACKGROUND: Atrial fibrillation (AF) is increasingly prevalent in society, and can elevate cardiac morbidity and mortality. Psychosis and gender are known to play important roles in the genesis of AF. However, it is not clear whether gender modulates the impact of different psychoses on the occurrences of AF. METHODS: We identified patients suffering from bipolar disorder and schizophrenia, with and without AF, using the Taiwan National Health Insurance nationwide database. The identified patient population consisted of 927,915 subjects (463,050 males and 464,865 females) from 2001 to 2008, which included 2,963 (3.2 ‰) schizophrenia patients (1,650 males and 1,313 females) and 5,112 (5.5 ‰) bipolar-disorder patients (1,934 males and 3,178 females). RESULTS: The male and female bipolar-disorder patients had higher prevalences of AF than did male (16.5 ‰ vs. 2.4 ‰, p < 0.001) and female (12.9 ‰ vs. 2.3 ‰, p < 0.001) schizophrenia patients. Furthermore, male and female bipolar-disorder patients had higher AF prevalences than did males (8.5 ‰, p < 0.001) and females (7.2 ‰, p < 0.001) in the general population. Schizophrenia patients had lower AF prevalence than the general population in male, but not in female gender. Males had a higher AF prevalence than females. However, male and female bipolar disorder and schizophrenia patients had similar AF prevalences. Those patients with schizophrenia and bipolar-disorder patients with AF were older than those without AF. CONCLUSIONS: Differing risk factors for AF were identified in bipolar-disorder and schizophrenia patients. Compared to the general population, gender may have different impacts on the occurrence of AF in psychosis patients. KEY WORDS: Atrial fibrillation; Bipolar disorder; Population-based study; Schizophrenia.
BACKGROUND:Atrial fibrillation (AF) is increasingly prevalent in society, and can elevate cardiac morbidity and mortality. Psychosis and gender are known to play important roles in the genesis of AF. However, it is not clear whether gender modulates the impact of different psychoses on the occurrences of AF. METHODS: We identified patients suffering from bipolar disorder and schizophrenia, with and without AF, using the Taiwan National Health Insurance nationwide database. The identified patient population consisted of 927,915 subjects (463,050 males and 464,865 females) from 2001 to 2008, which included 2,963 (3.2 ‰) schizophreniapatients (1,650 males and 1,313 females) and 5,112 (5.5 ‰) bipolar-disorderpatients (1,934 males and 3,178 females). RESULTS: The male and female bipolar-disorderpatients had higher prevalences of AF than did male (16.5 ‰ vs. 2.4 ‰, p < 0.001) and female (12.9 ‰ vs. 2.3 ‰, p < 0.001) schizophreniapatients. Furthermore, male and female bipolar-disorderpatients had higher AF prevalences than did males (8.5 ‰, p < 0.001) and females (7.2 ‰, p < 0.001) in the general population. Schizophreniapatients had lower AF prevalence than the general population in male, but not in female gender. Males had a higher AF prevalence than females. However, male and female bipolar disorder and schizophreniapatients had similar AF prevalences. Those patients with schizophrenia and bipolar-disorderpatients with AF were older than those without AF. CONCLUSIONS: Differing risk factors for AF were identified in bipolar-disorder and schizophreniapatients. Compared to the general population, gender may have different impacts on the occurrence of AF in psychosispatients. KEY WORDS: Atrial fibrillation; Bipolar disorder; Population-based study; Schizophrenia.
Authors: Elaine D Eaker; Lisa M Sullivan; Margaret Kelly-Hayes; Ralph B D'Agostino; Emelia J Benjamin Journal: Psychosom Med Date: 2005 Sep-Oct Impact factor: 4.312
Authors: Anil K Gehi; Samuel Sears; Neeta Goli; T Jennifer Walker; Eugene Chung; Jennifer Schwartz; Kathryn A Wood; Kimberly Guise; J Paul Mounsey Journal: J Cardiovasc Electrophysiol Date: 2012-03-19
Authors: Phillip J Tully; Jayme S Bennetts; Robert A Baker; Andrew D McGavigan; Deborah A Turnbull; Helen R Winefield Journal: Heart Lung Date: 2010-05-08 Impact factor: 2.210
Authors: B M Psaty; T A Manolio; L H Kuller; R A Kronmal; M Cushman; L P Fried; R White; C D Furberg; P M Rautaharju Journal: Circulation Date: 1997-10-07 Impact factor: 29.690
Authors: James B Kirkbride; Antonia Errazuriz; Tim J Croudace; Craig Morgan; Daniel Jackson; Jane Boydell; Robin M Murray; Peter B Jones Journal: PLoS One Date: 2012-03-22 Impact factor: 3.240