PURPOSE: The aim of this study was to assess the prevalence of atrial fibrillation (AF) in patients with Brugada syndrome (BrS) and their clinical characteristics in Taiwan. METHODS: The patient group consisted of 47 symptomatic BrS patients consecutively enrolled from 2000 to 2010. The definition of BrS patients with AF was a BrS patient with at least one episode of AF in a 12-lead electrogram or 24-hour holter (permanent, persistent or paroxysmal) during follow-up, or before diagnosis of BrS. RESULTS: Six BrS patients were identified with AF, and all of them were male. Two experienced sudden cardiac death (SCD), 2 presented with seizure and 4 with syncope. The mean age at onset of BrS was 47 ± 16 years, similar to those BrS patients without AF (45 ± 14, p = 0.67). Compared to those BrS patients without AF, significantly higher percentages of the BrS patients with AF presented with seizure and documented ventricular tachyarrhythmia (p = 0.02 and 0.03, respectively). Five of them had spontaneous Brugada type I electrogram, similar to those BrS patients without AF (p = 0.9). The SCN5A mutation rate is similar between BrS patients with AF and those without AF (p = 0.69). The prevalence of AF in BrS patients in Taiwan was 12.7% (6/47, 95% confidence interval 0.06-0.19) which is not significantly lower than the 20% prevalence found in the Caucasian population (p = 0.16). CONCLUSIONS: BrS patients with AF had distinct clinical features from those patients without AF in Taiwan. KEY WORDS: Atrial fibrillation; Brugada syndrome; Taiwan.
PURPOSE: The aim of this study was to assess the prevalence of atrial fibrillation (AF) in patients with Brugada syndrome (BrS) and their clinical characteristics in Taiwan. METHODS: The patient group consisted of 47 symptomatic BrS patients consecutively enrolled from 2000 to 2010. The definition of BrS patients with AF was a BrS patient with at least one episode of AF in a 12-lead electrogram or 24-hour holter (permanent, persistent or paroxysmal) during follow-up, or before diagnosis of BrS. RESULTS: Six BrS patients were identified with AF, and all of them were male. Two experienced sudden cardiac death (SCD), 2 presented with seizure and 4 with syncope. The mean age at onset of BrS was 47 ± 16 years, similar to those BrS patients without AF (45 ± 14, p = 0.67). Compared to those BrS patients without AF, significantly higher percentages of the BrS patients with AF presented with seizure and documented ventricular tachyarrhythmia (p = 0.02 and 0.03, respectively). Five of them had spontaneous Brugada type I electrogram, similar to those BrS patients without AF (p = 0.9). The SCN5A mutation rate is similar between BrS patients with AF and those without AF (p = 0.69). The prevalence of AF in BrS patients in Taiwan was 12.7% (6/47, 95% confidence interval 0.06-0.19) which is not significantly lower than the 20% prevalence found in the Caucasian population (p = 0.16). CONCLUSIONS: BrS patients with AF had distinct clinical features from those patients without AF in Taiwan. KEY WORDS: Atrial fibrillation; Brugada syndrome; Taiwan.
Authors: Charles Antzelevitch; Pedro Brugada; Martin Borggrefe; Josep Brugada; Ramon Brugada; Domenico Corrado; Ihor Gussak; Herve LeMarec; Koonlawee Nademanee; Andres Ricardo Perez Riera; Wataru Shimizu; Eric Schulze-Bahr; Hanno Tan; Arthur Wilde Journal: Heart Rhythm Date: 2005-04 Impact factor: 6.343
Authors: T Ikeda; H Sakurada; K Sakabe; T Sakata; M Takami; N Tezuka; T Nakae; M Noro; Y Enjoji; T Tejima; K Sugi; T Yamaguchi Journal: J Am Coll Cardiol Date: 2001-05 Impact factor: 24.094
Authors: Eva Delpón; Jonathan M Cordeiro; Lucía Núñez; Poul Erik Bloch Thomsen; Alejandra Guerchicoff; Guido D Pollevick; Yuesheng Wu; Jørgen K Kanters; Carsten Toftager Larsen; Jacob Hofman-Bang; Elena Burashnikov; Michael Christiansen; Charles Antzelevitch Journal: Circ Arrhythm Electrophysiol Date: 2008-08