Chia-Hung Chiang1, Chia-Jen Liu2, Ping-Jen Chen3, Hsin-Bang Leu4, Chien-Yi Hsu5, Po-Hsun Huang6, Tzeng-Ji Chen7, Shing-Jong Lin8, Jaw-Wen Chen9, Wan-Leong Chan10. 1. Division of Cardiology, Department of Medicine, Zhudong Veterans Hospital, Hsinchu; ; Division of Cardiology, Department of Medicine; ; Cardiovascular Research Center; ; Institute of Clinical Medicine; 2. Division of Hematology and Oncology, Department of Medicine; ; Department of Internal Medicine, National Yang-Ming University Hospital, Yilan; ; Institute of Public Health & School of Medicine, National Yang-Ming University, Taipei, Taiwan. 3. Department of Family Medicine and Department of Geriatric Medicine, Chi-Mei Medical Center, Tainan; 4. Division of Cardiology, Department of Medicine; ; Healthcare and Management Center; ; Cardiovascular Research Center; ; Institute of Clinical Medicine; 5. Division of Cardiology, Department of Medicine; ; Cardiovascular Research Center; 6. Division of Cardiology, Department of Medicine; ; Cardiovascular Research Center; ; Institute of Clinical Medicine; 7. Department of Family Medicine, Taipei Veterans General Hospital, Taipei; 8. Division of Cardiology, Department of Medicine; ; Department of Medical Research and Education; ; Cardiovascular Research Center; ; Institute of Clinical Medicine; 9. Division of Cardiology, Department of Medicine; ; Department of Medical Research and Education; ; Cardiovascular Research Center; ; Institute of Pharmacology; 10. Division of Cardiology, Department of Medicine; ; Healthcare and Management Center;
Abstract
BACKGROUND: Patients with autoimmune diseases have a high cardiovascular risk. However, few data are available on the risk of acute myocardial infarction (AMI) in patients diagnosed with primary Sjögren's syndrome (PSS). We conducted a large nationwide cohort study to investigate the possible association between PSS and the risk of AMI. METHODS: Between the years 2000-2006, a total of 5205 patients with newly diagnosed PSS and no history of AMI were identified from the Registry of Catastrophic Illness, a sub-dataset of the National Health Insurance Research Database in Taiwan. The control group, which consisted of subjects without systemic autoimmune disease or previous AMI, was matched by the date of enrollment, age, gender, history of coronary artery disease, diabetes, hypertension, chronic kidney disease, and hyperlipidemia. The study endpoints were the occurrence of AMI. RESULTS: Of the 5205 subjects with PSS and 5205 controls included in the study, 77 (35 PSS patients and 42 controls) developed AMI during the mean 3.7-year (interquartile range, 2.1-5.1 years) follow-up period. The incidence of AMI was similar in PSS patients and controls (1.91/1000 versus 2.25/1000 person-years). Multivariate analysis adjusted for baseline covariates demonstrated an insignificant association between PSS and AMI [adjusted hazard ratio, 0.86; 95% confidence interval (CI), 0.55-1.35; p = 0.506], suggesting that PSS does not increase the risk of AMI. CONCLUSIONS: PSS is not associated with a higher risk of subsequent AMI. KEY WORDS: Acute myocardial infarction; Atherosclerosis; Primary Sjögren's syndrome.
BACKGROUND:Patients with autoimmune diseases have a high cardiovascular risk. However, few data are available on the risk of acute myocardial infarction (AMI) in patients diagnosed with primary Sjögren's syndrome (PSS). We conducted a large nationwide cohort study to investigate the possible association between PSS and the risk of AMI. METHODS: Between the years 2000-2006, a total of 5205 patients with newly diagnosed PSS and no history of AMI were identified from the Registry of Catastrophic Illness, a sub-dataset of the National Health Insurance Research Database in Taiwan. The control group, which consisted of subjects without systemic autoimmune disease or previous AMI, was matched by the date of enrollment, age, gender, history of coronary artery disease, diabetes, hypertension, chronic kidney disease, and hyperlipidemia. The study endpoints were the occurrence of AMI. RESULTS: Of the 5205 subjects with PSS and 5205 controls included in the study, 77 (35 PSS patients and 42 controls) developed AMI during the mean 3.7-year (interquartile range, 2.1-5.1 years) follow-up period. The incidence of AMI was similar in PSS patients and controls (1.91/1000 versus 2.25/1000 person-years). Multivariate analysis adjusted for baseline covariates demonstrated an insignificant association between PSS and AMI [adjusted hazard ratio, 0.86; 95% confidence interval (CI), 0.55-1.35; p = 0.506], suggesting that PSS does not increase the risk of AMI. CONCLUSIONS: PSS is not associated with a higher risk of subsequent AMI. KEY WORDS: Acute myocardial infarction; Atherosclerosis; Primary Sjögren's syndrome.
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