Thomas Mabey1, Sittisak Honsawek1,2, Aree Tanavalee2, Pongsak Yuktanandana2, Vajara Wilairatana2, Yong Poovorawan3. 1. a Department of Biochemistry, Faculty of Medicine , Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society , Bangkok , Thailand ; 2. b Vinai Parkpian Orthopaedic Research Center, Department of Orthopaedics, Faculty of Medicine , Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society , Bangkok , Thailand ; 3. c Department of Pediatrics Faculty of Medicine, Center of Excellence in Clinical Virology , Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society , Bangkok , Thailand.
Abstract
OBJECTIVE: The objective of this study is to compare inflammatory cytokine levels in primary knee osteoarthritis (OA) patients and healthy controls. METHODS: A total of 32 knee OA patients and 14 healthy controls were enrolled. A multiplex immunoassay was utilized for 10 cytokines in plasma and synovial fluid. RESULTS: Plasma IL-2, IL-4, and IL-6 concentrations were significantly greater in knee OA patients than controls. Moreover, both plasma IL-4 and IL-6 were positively correlated with the radiographic severity of knee OA. CONCLUSIONS: Plasma IL-4 and IL-6 may serve as biomarkers reflecting the severity of OA.
OBJECTIVE: The objective of this study is to compare inflammatory cytokine levels in primary knee osteoarthritis (OA) patients and healthy controls. METHODS: A total of 32 knee OA patients and 14 healthy controls were enrolled. A multiplex immunoassay was utilized for 10 cytokines in plasma and synovial fluid. RESULTS: Plasma IL-2, IL-4, and IL-6 concentrations were significantly greater in knee OA patients than controls. Moreover, both plasma IL-4 and IL-6 were positively correlated with the radiographic severity of knee OA. CONCLUSIONS: Plasma IL-4 and IL-6 may serve as biomarkers reflecting the severity of OA.
Authors: E Folkesson; A Turkiewicz; N Ali; M Rydén; H V Hughes; J Tjörnstrand; P Önnerfjord; M Englund Journal: Osteoarthritis Cartilage Date: 2020-05-11 Impact factor: 6.576
Authors: Ravindra Kolhe; Monte Hunter; Siyang Liu; Ravirajsinh N Jadeja; Chetan Pundkar; Ashis K Mondal; Bharati Mendhe; Michelle Drewry; Mumtaz V Rojiani; Yutao Liu; Carlos M Isales; Robert E Guldberg; Mark W Hamrick; Sadanand Fulzele Journal: Sci Rep Date: 2017-05-17 Impact factor: 4.379
Authors: Eiva Bernotiene; Edvardas Bagdonas; Gailute Kirdaite; Paulius Bernotas; Ursule Kalvaityte; Ilona Uzieliene; Christian S Thudium; Heidi Hannula; Gabriela S Lorite; Mona Dvir-Ginzberg; Ali Guermazi; Ali Mobasheri Journal: Front Med (Lausanne) Date: 2020-10-21