Shuang Liu1,2, Xiaoqiang Li1,2, Hui Li1,2, Lei Guo1,2, Bo Zhang1,2, Zijun Gong1,2, Jubo Zhang1,2, Qinghai Ye1,2. 1. Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, P. R. China. 2. Key Laboratory of Carcinogenesis and Cancer Invasion, Fundan University, Ministry of Education, Shanghai, P. R. China.
Abstract
OBJECTIVES: To evaluate the effect of Pringle maneuver time on tumor recurrence following liver resection in patients with hepatocellular carcinoma (HCC). METHODS: In this single-center study, we retrospectively evaluated the effect of Pringle maneuver time on HCC recurrence over a 10-year period from 1999 to 2008 using a Cox regression analysis. RESULTS: This study enrolled a total of 2,368 patients. A Pringle maneuver time of 15 min was associated with HCC recurrence (log likelihood ratio test, P = 0.001). A Pringle maneuver time less than 15 min was not a significant risk factor for HCC recurrence (hazard ratio, HR = 0.97, P = 0.708). However, a Pringle maneuver time greater than 15 min was an independent predictor of HCC recurrence (HR = 1.41, P < 0.001). The patients who underwent the Pringle maneuver for over 15 min had lower overall survival (OS) and recurrence-free survival (RFS) than did those who either did not undergo the maneuver or underwent the maneuver for less than 15 min (both P < 0.001). CONCLUSIONS: These results suggest that a longer duration of the Pringle maneuver increases the risk of tumor recurrence in patients with HCC. However, a shorter duration of the Pringle maneuver decreases this risk. J. Surg. Oncol. 2016;114:112-118.
OBJECTIVES: To evaluate the effect of Pringle maneuver time on tumor recurrence following liver resection in patients with hepatocellular carcinoma (HCC). METHODS: In this single-center study, we retrospectively evaluated the effect of Pringle maneuver time on HCC recurrence over a 10-year period from 1999 to 2008 using a Cox regression analysis. RESULTS: This study enrolled a total of 2,368 patients. A Pringle maneuver time of 15 min was associated with HCC recurrence (log likelihood ratio test, P = 0.001). A Pringle maneuver time less than 15 min was not a significant risk factor for HCC recurrence (hazard ratio, HR = 0.97, P = 0.708). However, a Pringle maneuver time greater than 15 min was an independent predictor of HCC recurrence (HR = 1.41, P < 0.001). The patients who underwent the Pringle maneuver for over 15 min had lower overall survival (OS) and recurrence-free survival (RFS) than did those who either did not undergo the maneuver or underwent the maneuver for less than 15 min (both P < 0.001). CONCLUSIONS: These results suggest that a longer duration of the Pringle maneuver increases the risk of tumor recurrence in patients with HCC. However, a shorter duration of the Pringle maneuver decreases this risk. J. Surg. Oncol. 2016;114:112-118.
Authors: Kit Fai Lee; Charing C N Chong; Sunny Y S Cheung; John Wong; Andrew K Y Fung; Hon Ting Lok; Paul B S Lai Journal: World J Surg Date: 2019-12 Impact factor: 3.352
Authors: Kit Fai Lee; John Wong; Sunny Y S Cheung; Charing C N Chong; Joyce W Y Hui; Vivian Y F Leung; Simon C H Yu; Paul B S Lai Journal: World J Surg Date: 2018-10 Impact factor: 3.352
Authors: Samer Tohme; Marina V Kameneva; Hamza O Yazdani; Vikas Sud; Julie Goswami; Patricia Loughran; Hai Huang; Richard L Simmons; Allan Tsung Journal: Oncotarget Date: 2017-05-31