Literature DB >> 27121991

Therapeutic uses for Angiotensin-(1-7).

Alice Machado-Silva1, Danielle Passos-Silva2, Robson Augusto Santos2, Rubén Dario Sinisterra3.   

Abstract

INTRODUCTION: Angiotensin-(1-7) is a key component of the Renin-Angiotensin System, which can counter-regulate several deleterious effects caused by angiotensin II. Due to the potential for therapeutic use, several of its actions are specifically described in patents. AREAS COVERED: In this review, the authors describe a plethora of therapeutic uses for Angiotensin-(1-7), claimed and supported by experimental evidence in patent documents and applications. EXPERT OPINION: The clinical potential of Angiotensin-(1-7) as a therapeutic agent to treat several pathologies is evidenced by the variety of patents and clinical trials involving this peptide. Cancer treatment is one of the most advanced therapeutic areas, but clinical studies are also available in several other areas, such as cardiovascular, hematological, transplantation, surgical and medical procedures.

Entities:  

Keywords:  Angiotensin (1-7); Arg0; Mas receptor; PanCyte; RAS; TXA-127

Mesh：

Substances：

Year:  2016        PMID： 27121991     DOI： 10.1080/13543776.2016.1179283

Source DB:  PubMed          Journal:  Expert Opin Ther Pat        ISSN： 1354-3776            Impact factor:   6.674


  11 in total

Review 1.  Significance of angiotensin 1-7 coupling with MAS1 receptor and other GPCRs to the renin-angiotensin system: IUPHAR Review 22.

Authors:  Sadashiva S Karnik; Khuraijam Dhanachandra Singh; Kalyan Tirupula; Hamiyet Unal
Journal:  Br J Pharmacol       Date:  2017-03-09       Impact factor: 8.739

Review 2.  The renin-angiotensin system in cardiovascular autonomic control: recent developments and clinical implications.

Authors:  Amanda J Miller; Amy C Arnold
Journal:  Clin Auton Res       Date:  2018-11-09       Impact factor: 4.435

3.  Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina.

Authors:  Ping Zhu; Amrisha Verma; Tuhina Prasad; Qiuhong Li
Journal:  Mol Neurobiol       Date:  2019-08-07       Impact factor: 5.590

Review 4.  The ACE2/Angiotensin-(1-7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1-7).

Authors:  Robson Augusto Souza Santos; Walkyria Oliveira Sampaio; Andreia C Alzamora; Daisy Motta-Santos; Natalia Alenina; Michael Bader; Maria Jose Campagnole-Santos
Journal:  Physiol Rev       Date:  2018-01-01       Impact factor: 37.312

Review 5.  Renin angiotensin aldosterone inhibition in the treatment of cardiovascular disease.

Authors:  Carlos M Ferrario; Adam E Mullick
Journal:  Pharmacol Res       Date:  2017-05-29       Impact factor: 7.658

6.  SARS-CoV-2 Pathogenesis: Imbalance in the Renin-Angiotensin System Favors Lung Fibrosis.

Authors:  M Victoria Delpino; Jorge Quarleri
Journal:  Front Cell Infect Microbiol       Date:  2020-06-12       Impact factor: 5.293

7.  The angiotensin-(1-7)/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation.

Authors:  Alejandra Romero; Álvaro San Hipólito-Luengo; Laura A Villalobos; Susana Vallejo; Inés Valencia; Patrycja Michalska; Natalia Pajuelo-Lozano; Isabel Sánchez-Pérez; Rafael León; José Luis Bartha; María Jesús Sanz; Jorge D Erusalimsky; Carlos F Sánchez-Ferrer; Tania Romacho; Concepción Peiró
Journal:  Aging Cell       Date:  2019-02-17       Impact factor: 9.304

Review 8.  Counter-regulatory renin-angiotensin system in cardiovascular disease.

Authors:  Maria Paz Ocaranza; Jaime A Riquelme; Lorena García; Jorge E Jalil; Mario Chiong; Robson A S Santos; Sergio Lavandero
Journal:  Nat Rev Cardiol       Date:  2019-08-19       Impact factor: 32.419

9.  Angiotensin 1-7 Overexpression Mediated by a Capsid-optimized AAV8 Vector Leads to Significant Growth Inhibition of Hepatocellular Carcinoma In vivo.

Authors:  Yingying Mao; Nana Pei; Xinglu Chen; Huiying Chen; Renhe Yan; Na Bai; Andrew Li; Jinlong Li; Yanling Zhang; Hongyan Du; Baihong Chen; Colin Sumners; Xuejun Wang; Shengqi Wang; Hongwei Li
Journal:  Int J Biol Sci       Date:  2018-01-11       Impact factor: 6.580

10.  Ang-(1-7)/ MAS1 receptor axis inhibits allergic airway inflammation via blockade of Src-mediated EGFR transactivation in a murine model of asthma.

Authors:  Ahmed Z El-Hashim; Maitham A Khajah; Rhema S Babyson; Waleed M Renno; Charles I Ezeamuzie; Ibrahim F Benter; Saghir Akhtar
Journal:  PLoS One       Date:  2019-11-01       Impact factor: 3.240
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