Lara Milevoj Kopčinović1, Ana-Marija Domijan2, Ksenija Posavac3, Ivana Čepelak3, Tihana Žanić Grubišić3, Lada Rumora3. 1. a University Department of Chemistry, Medical School University Hospital Centre Sestre Milosrdnice , Zagreb , Croatia. 2. b Department of Pharmaceutical Botany, Faculty of Pharmacy and Biochemistry , University of Zagreb , Zagreb , Croatia. 3. c Department of Medical Biochemistry and Hematology , Faculty of Pharmacy and Biochemistry, University of Zagreb , Zagreb , Croatia.
Abstract
CONTEXT: Increased oxidative burden is found in chronic obstructive pulmonary disease (COPD). OBJECTIVE: To assess the association of ceruloplasmin, albumin, bilirubin, transferrin, thiols and malondialdehyde (MDA) with stable COPD. MATERIALS AND METHODS: Oxidative stress markers measured in 106 COPD patients and 45 healthy subjects were evaluated. RESULTS: Higher ceruloplasmin and MDA, and lower albumin, transferrin and thiols in COPD patients were found. Ceruloplasmin was the strongest single predictor of COPD. The model combining ceruloplasmin, albumin and thiols improved their individual diagnostic performances. CONCLUSIONS: Diagnostic characteristics of ceruloplasmin, albumin, transferrin, thiols and MDA suggest their potential value as additional tools in disease diagnosis.
CONTEXT: Increased oxidative burden is found in chronic obstructive pulmonary disease (COPD). OBJECTIVE: To assess the association of ceruloplasmin, albumin, bilirubin, transferrin, thiols and malondialdehyde (MDA) with stable COPD. MATERIALS AND METHODS: Oxidative stress markers measured in 106 COPDpatients and 45 healthy subjects were evaluated. RESULTS: Higher ceruloplasmin and MDA, and lower albumin, transferrin and thiols in COPDpatients were found. Ceruloplasmin was the strongest single predictor of COPD. The model combining ceruloplasmin, albumin and thiols improved their individual diagnostic performances. CONCLUSIONS: Diagnostic characteristics of ceruloplasmin, albumin, transferrin, thiols and MDA suggest their potential value as additional tools in disease diagnosis.
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