Literature DB >> 2711952

In vivo anaphylaxis in the rat: effects of phosphodiesterase inhibitors.

M J Post1, J D te Biesebeek, J Wemer, H H van Rooij, A J Porsius.   

Abstract

On the basis of their inhibitory capacities on the phosphodiesterase enzyme system, we studied the anti-anaphylactic effect of milrinone and sulmazole in comparison with theophylline. For this purpose anaphylactic shock was induced in actively sensitised, spontaneously breathing rats. Milrinone, sulmazole and theophylline reduced anaphylactic bronchoconstriction without affecting the antigen induced fall in blood pressure. Surprisingly, sulmazole reduced mortality significantly.

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Year:  1989        PMID： 2711952     DOI： 10.1007/BF02126565

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  5 in total

Review 1.  Overview of cardiac inotropic mechanisms.

Authors:  P K Siegl
Journal:  J Cardiovasc Pharmacol       Date:  1986       Impact factor: 3.105

2.  Multiple molecular forms of cyclic nucleotide phosphodiesterase in cardiac and smooth muscle and in platelets. Isolation, characterization, and effects of various reference phosphodiesterase inhibitors and cardiotonic agents.

Authors:  R E Weishaar; S D Burrows; D C Kobylarz; M M Quade; D B Evans
Journal:  Biochem Pharmacol       Date:  1986-03-01       Impact factor: 5.858

3.  Leukotrienes as mediators of ischemia and shock.

Authors:  A M Lefer
Journal:  Biochem Pharmacol       Date:  1986-01-15       Impact factor: 5.858

4.  A new method for inducing fatal, IgE-mediated, bronchial and cardiovascular anaphylaxis in the rat.

Authors:  J G Ufkes; M Ottenhof; R C Aalberse
Journal:  J Pharmacol Methods       Date:  1983-05

5.  The clinical significance of prostaglandins and thromboxane as mediators of septic shock.

Authors:  W Oettinger; D Berger; H G Beger
Journal:  Klin Wochenschr       Date:  1987-01-15
  5 in total

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