Literature DB >> 2711932

Glucocorticoid receptors in alveolar macrophages: methodological aspects of the determination of the number of glucocorticoid receptors per cell.

P T van Hal1, E Mulder, H C Hoogsteden, C Hilvering, R Benner.   

Abstract

Among patients with asthma or chronic obstructive pulmonary diseases the response to glucocorticoids varies considerably. To investigate the possible relationship between clinical response and number of glucocorticoid receptors in alveolar macrophages or their KD value a micro receptor assay was developed. Assay conditions were adjusted because of receptor occupancy by endogenous or therapeutically used glucocorticoids and high aspecific binding.

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Year:  1989        PMID： 2711932     DOI： 10.1007/BF02126584

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  7 in total

Review 1.  Mechanisms of glucocorticoid action in pulmonary disease.

Authors:  H G Morris
Journal:  Chest       Date:  1985-08       Impact factor: 9.410

2.  The oil-microcentrifuge assay: a rapid and sensitive method for analyzing specific [3H]estradiol binding in cultured cells.

Authors:  W H McLaughlin; R A Milius; L M Gill; S J Adelstein; W D Bloomer
Journal:  J Steroid Biochem       Date:  1984-05       Impact factor: 4.292

3.  A cellular abnormality in glucocorticoid resistant asthma.

Authors:  M C Poznansky; A C Gordon; I W Grant; A H Wyllie
Journal:  Clin Exp Immunol       Date:  1985-07       Impact factor: 4.330

4.  Alveolar macrophage and its participation in the inflammatory processes of allergic asthma.

Authors:  A B Tonnel; P Gossett; M Joseph; P Lassalle; J P Dessant; A Capron
Journal:  Bull Eur Physiopathol Respir       Date:  1986

5.  Glucocorticoid receptors, in human alveolar macrophages and peripheral blood cells.

Authors:  T Ozaki; S Yasuoka; T Nakayama; E Tsubura
Journal:  Clin Exp Immunol       Date:  1982-02       Impact factor: 4.330

6.  Alveolar macrophages in idiopathic pulmonary fibrosis have glucocorticoid receptors, but glucocorticoid therapy does not suppress alveolar macrophage release of fibronectin and alveolar macrophage derived growth factor.

Authors:  J G Lacronique; S I Rennard; P B Bitterman; T Ozaki; R G Crystal
Journal:  Am Rev Respir Dis       Date:  1984-09

7.  Glucocorticoid receptors and glucocorticoid sensitivity of human leukemic cells.

Authors:  K Kontula; L C Andersson; T Paavonen; G Myllylä; L Teerenhovi; P Vuopio
Journal:  Int J Cancer       Date:  1980-08       Impact factor: 7.396
  7 in total
  1 in total

1.  Time dependent production of cytokines and eicosanoids by human monocytic leukaemia U937 cells; effects of glucocorticosteroids.

Authors:  I M Garrelds; P T van Hal; R C Haakmat; H C Hoogsteden; P R Saxena; F J Zijlstra
Journal:  Mediators Inflamm       Date:  1999       Impact factor: 4.711
  1 in total

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