Stephan Walterspacher1, Johanna July1, Martin Kohlhäufl2, Peter Rzehak3, Wolfram Windisch4. 1. Clinic for Pneumology, Department of Internal Medicine, University Hospital Freiburg, Freiburg, Germany. 2. Klinik Schillerhöhe, Center for Pulmonology and Thoracic Surgery, Academic Teaching Hospital of the University of Tübingen, Stuttgart-Gerlingen, Germany. 3. Ludwig-Maximilians-University of Munich, Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital, University of Munich Medical Centre, Munich, Germany. 4. Department of Pneumology, Kliniken der Stadt Köln gGmbH, Cologne, University of Witten/Herdecke, Witten, Germany.
Abstract
BACKGROUND: Respiratory insufficiency in COPD may present as hypoxic and/or hypercapnic respiratory failure treated with long-term oxygen therapy (LTOT) and/or noninvasive ventilation (NIV) with LTOT. The Severe Respiratory Insufficiency Questionnaire (SRI) is a tool for the assessment of health-related quality of life (HRQOL) in subjects receiving NIV. However, it remains unclear whether the SRI is also capable of assessing and discriminating HRQOL in subjects receiving LTOT. METHODS: Stable subjects with COPD receiving LTOT or NIV + LTOT (NIV) were prospectively recruited and completed the SRI, lung function tests, and blood gases. Confirmatory factor analysis for construct validity and internal consistency reliability were calculated. RESULTS: One hundred fifty-five subjects were included (113 LTOT, 42 NIV). The Cronbach α coefficient of the 7 subscales ranged between 0.69 and 0.89 (LTOT) and between 0.79 and 0.93 (NIV), respectively. In both groups, confirmatory factor analysis revealed a one-factor model for the SRI summary scale; in 5 subscales, one- or 2-factor models could be established. Group differences in the SRI subsets were all P <.05 (except for physical functioning) with higher scores in subjects receiving NIV. CONCLUSIONS: The SRI showed high reliability and validity in subjects with COPD receiving LTOT. Subjects receiving LTOT had lower SRI scores, indicating a poorer HRQOL compared with subjects with established NIV and LTOT.
BACKGROUND:Respiratory insufficiency in COPD may present as hypoxic and/or hypercapnic respiratory failure treated with long-term oxygen therapy (LTOT) and/or noninvasive ventilation (NIV) with LTOT. The Severe Respiratory Insufficiency Questionnaire (SRI) is a tool for the assessment of health-related quality of life (HRQOL) in subjects receiving NIV. However, it remains unclear whether the SRI is also capable of assessing and discriminating HRQOL in subjects receiving LTOT. METHODS: Stable subjects with COPD receiving LTOT or NIV + LTOT (NIV) were prospectively recruited and completed the SRI, lung function tests, and blood gases. Confirmatory factor analysis for construct validity and internal consistency reliability were calculated. RESULTS: One hundred fifty-five subjects were included (113 LTOT, 42 NIV). The Cronbach α coefficient of the 7 subscales ranged between 0.69 and 0.89 (LTOT) and between 0.79 and 0.93 (NIV), respectively. In both groups, confirmatory factor analysis revealed a one-factor model for the SRI summary scale; in 5 subscales, one- or 2-factor models could be established. Group differences in the SRI subsets were all P <.05 (except for physical functioning) with higher scores in subjects receiving NIV. CONCLUSIONS: The SRI showed high reliability and validity in subjects with COPD receiving LTOT. Subjects receiving LTOT had lower SRI scores, indicating a poorer HRQOL compared with subjects with established NIV and LTOT.
Authors: Maximilian Wollsching-Strobel; Sarah Bettina Schwarz; Tim Mathes; Daniel Sebastian Majorski; Pouya Heidari; Doreen Kroppen; Friederike Sophie Magnet; Wolfram Windisch Journal: Int J Chron Obstruct Pulmon Dis Date: 2021-10-28
Authors: Sarah Bettina Schwarz; Tim Mathes; Daniel Sebastian Majorski; Maximilian Wollsching-Strobel; Doreen Kroppen; Friederike Sophie Magnet; Wolfram Windisch Journal: BMC Pulm Med Date: 2021-08-03 Impact factor: 3.317