| Literature DB >> 27118262 |
Bing Wu1, Chunping Zhang1, Lifang Zou1, Yucheng Ma2, Kangyu Huang2, Qiulan Lv1, Xi Zhang1, Shouyu Wang1, Yun Xue1, Zhihua Yi1, Tianyu Jia1, Shanhong Zhao1, Shuangmei Liu1, Hong Xu1, Guilin Li3, Shangdong Liang4.
Abstract
Diabetic autonomic neuropathy includes the sympathetic ganglionic dysfunction. P2X7 receptor in superior cervical ganglia (SCG) participated in the pathological changes of cardiac dysfunction. Abnormal expression of long noncoding RNAs (lncRNAs) was reported to be involved in nervous system diseases. Our preliminary results obtained from rat lncRNA array profiling revealed that the expression of the uc.48+ was significantly increased in the rat SCG in response to diabetic sympathetic pathology. In this study, we found that lncRNAuc.48+ and P2X7 receptor in the SCG were increased in type 2 diabetic rats and were associated with the cardiac dysfunction. The uc.48+ small interference RNA (siRNA) improved the cardiac autonomic dysfunction and decreased the up-regulation P2X7 and the ratio of phosphorylated extracellular regulated protein kinases1/2 (p-ERK1/2) to ERK1/2 in SCG of type 2 diabetic rats. In conclusion, lncRNA uc.48+ siRNA improved diabetic sympathetic neuropathy in type 2 diabetic rats through regulating the expression of P2X7 and ERK signaling in SCG.Entities:
Keywords: Long noncoding RNA; P2X(7) receptor; Superior cervical ganglia; Type 2 diabetes
Mesh：
Substances：
Year: 2016 PMID： 27118262 DOI： 10.1016/j.autneu.2016.04.001
Source DB: PubMed Journal: Auton Neurosci ISSN： 1566-0702 Impact factor: 3.145